STRUCTURE OF A BACTERIA TIR CONTAINING VIRULENCE FACTOR

含有毒力因子的细菌 TIR 的结构

• 批准号: 8170142
• 负责人: LIEH YOON LOW
• 金额: $ 0.1万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170142
• 关键词: Bacteria; Computer Retrieval of Information on Scientific Projects Database; Data; Family; Funding; Grant; Institution; Length; Methods; Molecular Conformation; N-terminal; Research; Research Personnel; Resources; Signal Transduction; Source; Structure; United States National Institutes of Health; Virulence Factors; dimer; insight

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In order to get insights into the function of this new family of virulence factors it is crucial to ascertain the conformation of the TIR domain inside the signaling active full length homodimer. We expect SAXS data to give us the orientation of the dimer: is the TIR domain opposing the TIR of the partner molecule or the N-terminal helical region? Having solved the structure of the TIR domain, our top priority is to find a quick method that could provide empirical evidence of the dimer organization because of its functional relevance.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 为了深入了解这个新的毒力因子家族的功能，确定信号传导活性全长同型二聚体内的TIR结构域的构象至关重要。我们希望SAXS数据能够给我们二聚体的取向：TIR域是相反的伴侣分子或N末端螺旋区域的TIR吗？解决了TIR域的结构后，我们的首要任务是找到一种快速方法，该方法可以提供二聚体组织的经验证据，因为其功能相关性。