STRUCTURE OF A BACTERIA TIR CONTAINING VIRULENCE FACTOR

含有毒力因子的细菌 TIR 的结构

• 批准号: 8170142
• 负责人: LIEH YOON LOW
• 金额: $ 0.1万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170142
• 关键词: Bacteria; Computer Retrieval of Information on Scientific Projects Database; Data; Family; Funding; Grant; Institution; Length; Methods; Molecular Conformation; N-terminal; Research; Research Personnel; Resources; Signal Transduction; Source; Structure; United States National Institutes of Health; Virulence Factors; dimer; insight

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In order to get insights into the function of this new family of virulence factors it is crucial to ascertain the conformation of the TIR domain inside the signaling active full length homodimer. We expect SAXS data to give us the orientation of the dimer: is the TIR domain opposing the TIR of the partner molecule or the N-terminal helical region? Having solved the structure of the TIR domain, our top priority is to find a quick method that could provide empirical evidence of the dimer organization because of its functional relevance.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 为了深入了解这个新的毒力因子家族的功能，确定信号传导活性全长同源二聚体内TIR结构域的构象是至关重要的。我们希望SAXS数据给我们的方向的二聚体：是TIR域相对于TIR的伴侣分子或N-末端螺旋区域？在解决了TIR结构域的结构之后，我们的首要任务是找到一种快速的方法，可以提供二聚体组织的经验证据，因为它的功能相关性。