CRYSTALLOGRAPHIC STUDIES OF VIRULENCE FACTORS, HOST-PATHOGEN INTERACTIONS, AND O

毒力因子、宿主-病原体相互作用和 O 的晶体学研究

• 批准号: 8362218
• 负责人: LIEH YOON LOW
• 金额: $ 0.44万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362218
• 关键词: Complex; Disease; Drug Design; Funding; Grant; Immune; Inflammation; Integration Host Factors; National Center for Research Resources; Phase; Principal Investigator; Proteins; Radiation; Research; Research Infrastructure; Resources; Source; Structure; Therapeutic; United States National Institutes of Health; Virulence Factors; Work; anthrax toxin; cell motility; cost; design; inhibitor/antagonist; neutralizing antibody; pathogen; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The major focuses are anthrax toxin and virulence factors from other high priority pathogens and emerging diseases, and their interactions with host factors, as well as host proteins involved in cell migration and inflammation. The work involves ab initio structure determination by MAD phasing, studies of protein-inhibitor complexes for rational drug design, and complexes with neutralizing antibodies for designing immune therapeutics.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 主要重点是其他高优先病原体和新兴疾病的炭疽毒素和毒力因子，以及它们与宿主因素的相互作用，以及与细胞迁移和炎症有关的宿主蛋白。这项工作涉及通过疯狂的相分化的从头算结构的确定，对理性药物设计的蛋白质抑制剂复合物的研究以及具有中和抗体设计免疫治疗剂的复合物。