KV CHANNEL IN LIPID MEMBRANES (2D CRYSTALS OF KVAP)

脂质膜中的 KV 通道（KVAP 的二维晶体）

• 批准号: 8168601
• 负责人: Qiu-Xing Jiang
• 金额: $ 1.08万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-15 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168601
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; Institution; Lipids; Membrane Lipids; Molecular Conformation; Potassium; Proteins; Research; Research Personnel; Resolution; Resources; Source; Structure; United States National Institutes of Health; three dimensional structure; voltage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will be aimed at obtaining structures of a voltage-gated potassium (Kv) channel in lipid membranes. There are at least two distinct conformations for a Kv channel and we want to obtain both structures at 5-9 angstrom resolutions so that we can deduce the secondary structures. If conditions permit, we will pursue structures at higher resolutions that will reveal the structural details for the strong lipid-protein interaction that has been demonstrated to be critical for voltage-gating. The immediate goal is to obtain the 3D structure of a 2D crystal form that is currently available.

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