KV CHANNEL IN LIPID MEMBRANES (2D CRYSTALS OF KVAP)

脂质膜中的 KV 通道（KVAP 的二维晶体）

• 批准号: 8361108
• 负责人: Qiu-Xing Jiang
• 金额: $ 1.23万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361108
• 关键词: Electron Microscopy; Funding; Goals; Grant; Lipids; Membrane Lipids; Molecular Conformation; National Center for Research Resources; Potassium; Principal Investigator; Proteins; Research; Research Infrastructure; Resolution; Resources; Source; Structure; United States National Institutes of Health; cost; macromolecule; three dimensional structure; voltage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project will be aimed at obtaining structures of a voltage-gated potassium (Kv) channel in lipid membranes. There are at least two distinct conformations for a Kv channel and we want to obtain both structures at 5-9 Angstrom resolution so that we can deduce the secondary structures. If conditions permit, we will pursue structures at higher resolutions that will reveal the structural details for the strong lipid-protein interaction that has been demonstrated to be critical for voltage-gating. The immediate goal is to obtain the 3D structure of a 2D crystal form that is currently available.

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