STRUCTURAL INVESTIGATION OF PROTEINS IN THE ENDOCYTIC PATHWAY

内吞途径中蛋白质的结构研究

• 批准号: 8169222
• 负责人: Pietro De Camilli
• 金额: $ 0.35万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169222
• 关键词: Cells; Cellular biology; Computer Retrieval of Information on Scientific Projects Database; Endocytosis; Exocytosis; Funding; Goals; Grant; Institution; Investigation; Knowledge; Learning; Membrane; Neurons; Organelles; Pathway interactions; Process; Proteins; Research; Research Personnel; Resources; Source; Synapses; Synaptic Transmission; Synaptic Vesicles; United States National Institutes of Health; interest; neurotransmitter release; protein complex; trafficking

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in the cell biology of neuronal synapses, with emphasis on synaptic vesicles, the special secretory organelles that store and release neurotransmitters. Our goal is to learn about synaptic transmission but also to advance general knowledge in the field of exo- and endocytosis. In these processes, protein machineries are used to traffic specific cargos within the cell through membrane remodeling, by both changing the composition of the membrane and by deforming the membrane. In order to study this process, we are taking a structural approach in order to understand how these protein complexes are formed.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们感兴趣的是神经元突触的细胞生物学，重点是突触囊泡，储存和释放神经递质的特殊分泌细胞器。 我们的目标是了解突触传递，但也推进外吞和内吞领域的一般知识。在这些过程中，蛋白质机器通过改变膜的组成和使膜变形，用于通过膜重塑在细胞内运输特定货物。 为了研究这个过程，我们正在采取结构方法，以了解这些蛋白质复合物是如何形成的。