CRYSTAL STRUCTURE OF PGP3

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 衣原体代表一组革兰氏阴性细胞内病原体，已知其在人类中引起各种健康问题。一般认为衣原体感染引起的疾病是由于衣原体感染引起的宿主炎症反应。几种衣原体携带7.5Kb的隐蔽质粒。该质粒编码8个推定的开放阅读框（pORF）。pORF 5编码Pgp 3，Pgp 3是主要在感染后12小时在衣原体感染细胞的胞质溶胶中检测到的毒力因子。pgp 3由所有具有隐蔽质粒的衣原体分泌。它与宿主细胞信号通路相互作用，包括激活宿主炎症基因。Pgp 3的结构可以提供有价值的信息，以帮助了解炎症反应的激活和衣原体的发病机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chlamydia represents a group of gram negative intracellular pathogens that are known to cause various health problems in humans. It is generally accepted that Chlamydia-induced diseases are due to host inflammatory responses caused by chlamydial infection. Several chlamydial species carry a 7.5 Kb cryptic plasmid. The plasmid encodes eight putative open reading frames (pORF). pORF5 encodes Pgp3 which is a virulence factor that is mainly detected in the cytosol of Chlamydia infected cells 12 hours after infection. Pgp3 is secreted by all chlamydial species that have the cryptic plasmid. It interacts with the host cell signaling pathway including the activation of host inflammatory genes. The structure of Pgp3 can provide valuable information to help understand the activation of the inflammatory response and chlamydial pathogenesis.