SYNCHROTRON--SUPEROXIDE DISMUTASE, DIPHTHERIA TOXIN, DE NOVO DESIGNED PEPTIDES

肌萎缩侧索硬化症（ALS或卢伽雷氏病）是 神经退行性疾病的特征是进行性 脊髓和大脑中大型运动神经元的破坏。 大约10%的ALS患者有遗传性 （家族性）形式的疾病（FALS）显示紧密的遗传连锁 这种疾病和一种编码细胞溶质铜/锌结合的基因之间的联系 超氧化物歧化酶（SOD 1）。 我们希望将ALS功能障碍 具有Cu/ZnSOD结构的人SOD的晶体学分析 发现的突变体

Amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) is neurodegenerative disorder characterized by the progressive destruction of large motor neurons in the spinal cord and brain. Approximately 10% of ALS-afflicted individuals having the inherited (familial) form of the disease (FALS) display tight genetic linkage between the disorder and a gene encoding a cytosolic Cu/Zn-binding superoxide dismutase (SOD1). We desire to correlate ALS misfunction withCu/ZnSOD structure via crystallographic analysis of human SOD mutants found in FALS patients.