HISTONE METHYLATION AND EPIGENETIC CONTROL OF THE GENOME

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 组蛋白的残基特异性甲基化导致不同的表观遗传状态。但是组蛋白 甲基转移酶（将甲基添加到组蛋白的酶）和组蛋白脱甲基酶 （从组蛋白中去除甲基的酶）靶向特定的染色体 域没有很好地理解。更重要的是，除了几个著名的 例如，细胞机器如何识别这些修饰尚不清楚。我们将 从裂殖酵母中纯化组蛋白甲基转移酶和脱甲基酶复合物， 调节组蛋白甲基化的新蛋白质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Residue specific methylation of histones results in diverse epigenetic states. But how histone methyltransferases (enzymes that add methyl group to histones) and histone demethylases (enzymes that remove methyl group from histones) are targeted to specific chromosome domains are not well understood. More importantly, apart from several well-known examples, how the cellular machinery recognizes these modifications is not clear. We will purify histone methyltransferase and demethylases complexes from fission yeast to identify novel proteins that regulate histone methylation.