DSHRM SD2 DOMAIN

DSHRM SD2 域

• 批准号: 8170661
• 负责人: ANDREW Paul VANDEMARK
• 金额: $ 0.34万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170661
• 关键词: Binding; Biological Process; Birth; Cell Shape; Computer Retrieval of Information on Scientific Projects Database; Development; Embryonic Development; Funding; Grant; Homologous Gene; Human; Institution; Neural Tube Closure; Neural Tube Defects; Play; Process; Proteins; Research; Research Personnel; Resources; Role; Source; Structure; Translating; United States National Institutes of Health; migration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Formation and closure of the neural tube during embryogenesis and development is a precisely controlled process requiring alternations in cell shape, migration, and differientation. Neural tube defects resulting from deviations in this process are found in approximately 1 in 1000 human births. We have identified, expressed, and purified a region of the Shroom protein which plays an essential role in this process. By determining its structure, we will about the fold of this domain (it has no known structural homologs), how it interacts with its binding partners, and most importantly, how these interactions are translated into biological function.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 胚胎发生和发育过程中神经管的形成和闭合是一个精确控制的过程，需要在细胞形状，迁移和差异方面进行交替。 在此过程中偏差引起的神经管缺陷，大约有1000个人类分娩中的1个。 我们已经确定，表达和纯化了芝士蛋白的区域，该区域在此过程中起着至关重要的作用。 通过确定其结构，我们将围绕该域的折叠（它没有已知的结构同源物），如何与其结合伙伴相互作用，最重要的是，这些相互作用如何转化为生物学功能。