DSHRM SD2 DOMAIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 胚胎发生和发育期间神经管的形成和关闭是一个精确控制的过程，需要改变细胞的形状、迁移和分化。由这一过程中的偏差导致的神经管缺陷在大约1000名人类新生儿中被发现。我们已经鉴定、表达和纯化了蘑菇蛋白的一个区域，该区域在这一过程中起着至关重要的作用。通过确定其结构，我们将了解这个结构域的折叠(它没有已知的结构同源)，它如何与其结合伙伴相互作用，以及最重要的是，这些相互作用是如何转化为生物功能的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Formation and closure of the neural tube during embryogenesis and development is a precisely controlled process requiring alternations in cell shape, migration, and differientation. Neural tube defects resulting from deviations in this process are found in approximately 1 in 1000 human births. We have identified, expressed, and purified a region of the Shroom protein which plays an essential role in this process. By determining its structure, we will about the fold of this domain (it has no known structural homologs), how it interacts with its binding partners, and most importantly, how these interactions are translated into biological function.