DSHRM SD2 DOMAIN

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在胚胎发生和发育过程中，神经管的形成和闭合是一个精确控制的过程，需要改变细胞的形状、迁移和分化。 这一过程中的偏差导致的神经管缺陷在大约千分之一的新生儿中发现。 我们已经鉴定、表达和纯化了在这一过程中起重要作用的蘑菇蛋白的一个区域。 通过确定其结构，我们将了解该结构域的折叠（它没有已知的结构同源物），它如何与其结合伴侣相互作用，最重要的是，这些相互作用如何转化为生物功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Formation and closure of the neural tube during embryogenesis and development is a precisely controlled process requiring alternations in cell shape, migration, and differientation. Neural tube defects resulting from deviations in this process are found in approximately 1 in 1000 human births. We have identified, expressed, and purified a region of the Shroom protein which plays an essential role in this process. By determining its structure, we will about the fold of this domain (it has no known structural homologs), how it interacts with its binding partners, and most importantly, how these interactions are translated into biological function.