THE PAF1 TRANSCRIPTION ELONGATION COMPLEX

PAF1 转录延伸复合物

• 批准号: 8170671
• 负责人: ANDREW Paul VANDEMARK
• 金额: $ 0.46万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170671
• 关键词: Binding; Chromatin; Complex; Computer Retrieval of Information on Scientific Projects Database; Elongation Factor; Funding; Genes; Genetic Transcription; Goals; Grant; Histones; Institution; Maintenance; Polymerase; Post-Translational Protein Processing; RNA Polymerase II; RNA Processing; Research; Research Personnel; Resources; Sequence Homology; Source; Thinking; Transcription Elongation; United States National Institutes of Health; chromatin modification; insight

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Transcription is a basic, essential function that contered around the activity of a polymerase (often RNA polymerase II), but efficient transcription also requires the concerted efforts of numerous addition regulatory factors. These factors assist in various ways, for example by diminishing the physical barrier provided by the chromatin template as maintaining the appropriate post-translational modifications on the histones. The five subunit Paf1 complex is a transcription elongation factor that is required for the efficient transcription many genes, the maintenance of active chromatin modifications, and for proper 3' processing of RNA. It is not known how Paf1 coordinates these functions and there is little structural information or clues from sequence homology to direct our thinking about the mechanism of Paf1c function. We are hoping to gain insight into this through structural analysis of the Paf1 complex as well as isolated domains and complexes with various binding partners. The end goal is to develop an understanding of how Paf1c functions within the context of the transcription machinery.

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