COMPLEX OF FPPS-PV
COMPLEX OF FPPS-PV
批准号:
8170665
负责人:
Eric Oldfield
金额:
$0.41万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-07-01 至 2011-06-30
关键词:
AnabolismCarotenoidsCommitCommunitiesComplexComputer Retrieval of Information on Scientific Projects DatabaseComputing MethodologiesDevelopmentFundingGrantHumanInstitutionMethicillin ResistanceMusOrangesPhysical condensationProcessReactive Oxygen SpeciesResearchResearch PersonnelResistanceResourcesSourceSqualene SynthetaseStaphylococcus aureusUnited States National Institutes of HealthVirulence FactorsVirulentWorkbasedehydrosqualenedesignhypercholesterolemiainhibitor/antagonistisoprenoidkillingsneutrophilresistant strainstaphyloxanthin
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
We are using x-ray and computational methods to guide the development of molecules that inhibit formation of the orange carotenoid virulence factor, staphyloxanthin, in S. aureus. The first committed step in staphyloxanthin biosynthesis is the condensation of two molecules of the isoprenoid farnesyldiphosphate (FPP) to form dehydrosqualene. In recent preliminary work, we have discovered that phosphonosulfonates (human squalene synthase inhibitors which have been developed to treat hypercholesterolemia) also block staphyloxanthin biosynthesis in S. aureus, at 200 nM levels. The resulting S. aureus (L. aureus=golden) are white, non-infective in mice and are killed by neutrophils, since they have decreased defenses to reactive oxygen species (ROS). In Aim 1, we will develop more potent and selective compounds, using NMR, x-ray and computational methods to guide the design process. If successful, this work would be of importance given the increasing number of virulent, community acquired S. aureus and methicillin resistant strains which are becoming highly resistant to ROS based killing.
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Next generation bisphosphonates for chemo- and immuno-therapy
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批准号:8444316
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项目类别:
-
资助金额:$29.71万
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财政年份:2011
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负责人:Eric Oldfield
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依托单位:
Next generation bisphosphonates for chemo- and immuno-therapy
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批准号:8627146
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项目类别:
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资助金额:$30.66万
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财政年份:2011
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负责人:Eric Oldfield
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依托单位:
Next generation bisphosphonates for chemo- and immuno-therapy
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批准号:8825340
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项目类别:
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资助金额:$31.61万
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财政年份:2011
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负责人:Eric Oldfield
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依托单位:
Next generation bisphosphonates for chemo- and immuno-therapy
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批准号:8085202
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项目类别:
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资助金额:$31.64万
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财政年份:2011
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负责人:Eric Oldfield
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依托单位:
Prenyl Diphosphate Synthase Inhibitors
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批准号:6846172
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项目类别:
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资助金额:$3.17万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
Prenyldiphosphate Synthase Inhibitors: Novel Anti-Infective Agents
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批准号:7686803
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项目类别:
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资助金额:$31.87万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
Prenyl Synthase Inhibitors: Novel Anti-Infective Agents
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批准号:7984564
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项目类别:
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资助金额:$35.17万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
Prenyl Diphosphate Synthase Inhibitors
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批准号:6622937
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项目类别:
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资助金额:$31.57万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
Prenyl Synthase Inhibitors: Novel Anti-Infective Agents
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批准号:8532682
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项目类别:
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资助金额:$33.53万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
Prenyl Diphosphate Synthase Inhibitors
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批准号:6459345
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项目类别:
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资助金额:$31.59万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
Prenyl Diphosphate Synthase Inhibitors
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批准号:6749497
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项目类别:
-
资助金额:$36.03万
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财政年份:2002
-
负责人:Eric Oldfield
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依托单位:
Structure, Function and Inhibition of [4Fe-4S] Proteins
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批准号:8758404
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项目类别:
-
资助金额:$35.69万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
Prenyl Synthase Inhibitors: Novel Anti-Infective Agents
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批准号:8324616
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项目类别:
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资助金额:$34.75万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
Prenyldiphosphate Synthase Inhibitors: Novel Anti-Infective Agents
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批准号:7142806
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项目类别:
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资助金额:$32.96万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
Prenyldiphosphate Synthase Inhibitors: Novel Anti-Infective Agents
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批准号:7281980
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项目类别:
-
资助金额:$31.96万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
Prenyldiphosphate Synthase Inhibitors: Novel Anti-Infective Agents
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批准号:7492964
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项目类别:
-
资助金额:$31.91万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
Structure, Function and Inhibition of [4Fe-4S] Proteins
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批准号:8920593
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项目类别:
-
资助金额:$35.69万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
Prenyl Synthase Inhibitors: Novel Anti-Infective Agents
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批准号:8128720
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项目类别:
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资助金额:$34.76万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
Prenyl Diphosphate Synthase Inhibitors
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批准号:6898743
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项目类别:
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资助金额:$31.54万
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财政年份:2002
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负责人:Eric Oldfield
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依托单位:
MEMBRANE PEPTIDE STRUCTURE VIA NMR & QUANTUM CHEMISTRY
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批准号:6309034
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项目类别:
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资助金额:$2.74万
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财政年份:2000
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负责人:Eric Oldfield
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依托单位:
海外基金