CHOLESTEROL REMOVAL BY HDL PARTICLES

通过 HDL 颗粒去除胆固醇

• 批准号: 8170977
• 负责人: ENRICO GRATTON
• 金额: $ 5.67万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170977
• 关键词: Cells; Cellular Membrane; Cholesterol; Computer Retrieval of Information on Scientific Projects Database; Excision; Funding; Grant; High Density Lipoproteins; Image; Institution; Liver; Membrane; Photons; Process; Research; Research Personnel; Resources; Source; Sterols; System; United States National Institutes of Health; Vesicle; laurdan; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. -HDL are considered to be the initial acceptors of cellular cholesterol and the first step in the reverse cholesterol process, the process where cholesterol is transported from the cellular membrane to the liver to be degraded. The existence in the membrane of cholesterol domains, so-called lipd-rafts will regulate the efflux and the accessibility of the sterol molecules. We studied how this process occurs using LAURDAN GP imaging with 2-photon excitation and as a membrane system in Giant Unilamellar Vesicles and cells.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 -HDL 被认为是细胞胆固醇的初始受体，也是胆固醇逆向过程的第一步，即胆固醇从细胞膜转运到肝脏进行降解的过程。膜中存在的胆固醇结构域，即所谓的脂筏，将调节甾醇分子的流出和可及性。 我们使用 LAURDAN GP 成像和 2 光子激发以及作为巨型单层囊泡和细胞中的膜系统研究了这一过程是如何发生的。