EXTRACTING WIRING DIAGRAMS FROM NEURONAL CIRCUITS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 神经元电路的线路图可以从连续切割的超薄(50 Nm)切片的电子显微镜(EM)图像中获得。在哺乳动物的大脑中，即使是局部电路也可能在太空中跨越数百至数千微米。以纳米分辨率拍摄的数百微米的图像会消耗几十亿字节的存储空间。我们正在与PSC的人员合作，开发一条高吞吐量的管道，用于处理和分析这些非常庞大的数据集。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The wiring diagrams of neuronal circuits may be obtained from electron microscopy (EM) images of serially cut, ultrathin (<50 nm) sections through nervous tissue. In the mammalian brain, even local circuits may span hundreds to thousands of microns in space. Images spanning hundreds of microns at nanometer resolution consume many gigabytes of storage. We are working with people at PSC to develop a high throughput pipeline for processing and analysis of these very large data sets.