EXTRACTING WIRING DIAGRAMS FROM NEURONAL CIRCUITS

从神经元电路中提取接线图

• 批准号: 8364225
• 负责人: R CLAY REID
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364225
• 关键词: Biomedical Research; Brain; Data Set; Electron Microscopy; Funding; Grant; High Performance Computing; Image; National Center for Research Resources; Nerve Tissue; Neurons; Principal Investigator; Process; Research; Research Infrastructure; Resolution; Resources; Source; United States National Institutes of Health; Work; cost; nanometer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The wiring diagrams of neuronal circuits may be obtained from electron microscopy (EM) images of serially cut, ultrathin (<50 nm) sections through nervous tissue. In the mammalian brain, even local circuits may span hundreds to thousands of microns in space. Images spanning hundreds of microns at nanometer resolution consume many gigabytes of storage. We are working with people at PSC to develop a high throughput pipeline for processing and analysis of these very large data sets.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 神经元回路的接线图可以从通过神经组织连续切割的切片（<50 nm）的电子显微镜（EM）图像获得。在哺乳动物的大脑中，即使是局部电路也可能跨越数百到数千微米的空间。以纳米分辨率跨越数百微米的图像消耗许多千兆字节的存储。我们正在与PSC的人员合作开发一个高吞吐量管道，用于处理和分析这些非常大的数据集。