CLINICAL FASTEEM INSTRUMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们研究了漫反射和本征荧光光谱相结合在诊断宫颈发育不良、口腔癌、动脉粥样硬化和乳腺癌中的应用。我们正在开发一种迷你DRS/IFS临床仪器，将用于 LBRC之外的用户。这个项目的目的是促进光学光谱学的临床转化研究；并使年轻/新的研究人员熟悉诊断光谱学的方法。LBRC将提供能够收集漫反射白光光谱反射率和340 nm激发荧光的DRS/IFS光谱仪。利用DRS/IFS光纤探头在~1秒内获得光谱，该探头对1mm2的组织区域进行采样。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have investigated the usage of the combination of diffuse reflectance and intrinsic fluorescence spectroscopy to diagnose cervical dysplasia, oral cancer, atherosclerosis, and breast cancer. We are developing a mini-DRS/IFS clinical instrument that will be available for users outside of the LBRC. The purposes of this project are to foster clinical translational research in optical spectroscopy; and to familiarize young/new investigators with the methods of diagnostic spectroscopy. The LBRC will provide DRS/IFS spectroscopy instrument capable of collecting diffuse white light spectral reflectance and 340nm-excited fluorescence light. The spectra are acquired in ~1 sec by means of a DRS/IFS optical fiber probe, which samples 1mm2 regions of tissue.