CLINICAL FASTEEM INSTRUMENT

临床 FASTEEM 仪器

• 批准号: 8170406
• 负责人: ZOYA VOLYNSKAYA
• 金额: $ 1.9万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170406
• 关键词: Atherosclerosis; Cervical dysplasia; Clinical; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Diagnostic Procedure; Diffuse; Fluorescence; Fluorescence Spectroscopy; Fostering; Funding; Grant; Institution; Light; Optics; Research; Research Personnel; Resources; Sampling; Source; Spectrum Analysis; Tissues; Translational Research; United States National Institutes of Health; instrument; malignant breast neoplasm; malignant mouth neoplasm; optical fiber

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have investigated the usage of the combination of diffuse reflectance and intrinsic fluorescence spectroscopy to diagnose cervical dysplasia, oral cancer, atherosclerosis, and breast cancer. We are developing a mini-DRS/IFS clinical instrument that will be available for users outside of the LBRC. The purposes of this project are to foster clinical translational research in optical spectroscopy; and to familiarize young/new investigators with the methods of diagnostic spectroscopy. The LBRC will provide DRS/IFS spectroscopy instrument capable of collecting diffuse white light spectral reflectance and 340nm-excited fluorescence light. The spectra are acquired in ~1 sec by means of a DRS/IFS optical fiber probe, which samples 1mm2 regions of tissue.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们已经研究了漫反射和固有荧光光谱的组合用于诊断宫颈发育不良、口腔癌、动脉粥样硬化和乳腺癌。我们正在开发一种mini-DRS/IFS临床仪器， LBRC之外的用户。该项目的目的是促进光谱学的临床转化研究;并使年轻/新的研究人员熟悉诊断光谱学的方法。LBRC将提供能够收集漫白色光谱反射率和340 nm激发荧光的DRS/IFS光谱仪器。光谱通过DRS/IFS光纤探头在约1秒内采集，该探头对1 mm 2的组织区域进行采样。