EVALUATION OF QUALITY OF MACROMOLECULAR CRYSTALS

高分子晶体的质量评价

• 批准号: 8171999
• 负责人: VUKICA SRAJER
• 金额: $ 1.95万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171999
• 关键词: Anodes; Computer Retrieval of Information on Scientific Projects Database; Data; Evaluation; Funding; Grant; Home environment; Image; Institution; Process; Research; Research Personnel; Resources; Roentgen Rays; Source; Speed; Synchrotrons; Testing; Training; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. BioCARS is offering crystal evaluation sessions where beamtime is allocated on a short notice to local user groups to test and evaluate their new crystals. A critical part of any crystallographic project is optimization and evaluation of crystal quality and new crystal forms. This process is usually painstakingly done on a rotating anode at the home institution. We propose to continue with offering such evaluation at the Sector 14. Very intense synchrotron X-ray source provides important advantages: it greatly speeds up the process, obtained diffraction images provide better indication of crystal quality and testing of small or weakly diffracting crystals becomes possible. Our previous evaluation sessions have proven very popular and valuable to local users. We are offering these sessions only to already registered APS users with current training, so some of the data collected under this proposal could also be associated with other general user proposals.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 BioCARS正在提供晶体评估会议，在短时间内将光束时间分配给当地用户组，以测试和评估他们的新晶体。任何晶体学项目的一个关键部分是优化和评估晶体质量和新的晶体形式。这个过程通常是在家庭机构的旋转阳极上辛苦完成的。我们建议继续在第14区提供这种评估。非常强的同步加速器X射线源提供了重要的优势：它大大加快了过程，获得的衍射图像提供了更好的晶体质量指示，并且可以测试小或弱衍射晶体。 我们以前的评估会议已被证明是非常受欢迎的和有价值的本地用户。 我们只向已经注册并接受过当前培训的APS用户提供这些课程，因此在此提案下收集的一些数据也可以与其他一般用户提案相关联。