CRYSTAL SCREENING

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 BioCARS提供了一系列的晶体筛选会议，在那里当地的用户群体能够在短时间内评估新的晶体。 晶体生长和优化的一个重要部分是评估晶体质量和新的晶体形式。 这个过程通常是在家庭机构的旋转阳极上辛苦完成的。 我们建议在APS进行这种筛选，因为同步辐射的光束强度和质量有所提高。 除了大大加快过程之外，在APS获得的衍射图像应该更好地指示晶体质量。 我们以前的诊所已被证明是非常受欢迎和有用的本地用户。 我们仅向当前接受过培训的注册APS用户提供这些筛选会话，因此根据此提案收集的一些数据也可能与其他一般用户提案相关联。 考虑到不同用户组的收集以及添加新样本和人员的短时间通知，绝对不允许使用危险样本或材料。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. BioCARS is offering a series of crystal screening sessions, where local user groups are able to evaluate new crystals at short notice. An important part of crystal growth and optimization is evaluating crystal quality and new crystal forms. This process is usually painstakingly done on a rotating anode at the home institution. We propose to do this screening at the APS because of the increased beam intensity and quality of synchrotron radiation. Besides greatly speeding up the process, diffraction images obtained at the APS should give a better indication of crystal quality. Our previous clinics have proven very popular and useful to local users. We are only offering these screening sessions to registered APS users with current training, so some of the data collected under this proposal could also be associated with other general user proposals. Absolutely no hazardous samples or materials will be allowed given the collection of different user groups and short notice for addition of new samples and personnel.