POLYMAVIRUS IN HUMAN RENAL ALLOGRAFT TISSUE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 多达50%的健康成年人的肾脏中潜伏着多发性病毒。在使用免疫抑制药物的肾移植患者中，病毒的重新激活可能导致多病毒移植物肾病(PVAN)。PVAN是一种研究不足且令人痛苦的疾病，经常导致移植物丢失。正在提出的这项研究探讨了病毒基因组结构的变化可能在这种疾病的开始和随后的发展中发挥重要作用的概念。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polymavirus is latent in the kidney of up to 50% of healthy adults. In kidney transplant patients maintained on immunosuppressive drugs, reactivation of virus can result in polymovirus allograft nephropathy (PVAN). PVAN is an inadequately studied and distressing condidtion that frequently leads to graft loss. The study being proposed explores the notion that changes in viral genomic structure might play an important role in the initiation and subsequent progression of this disease