POLYMAVIRUS IN HUMAN RENAL ALLOGRAFT TISSUE

人肾同种异体移植组织中的多聚病毒

• 批准号: 8171864
• 负责人: PARMJEET S RANDHAWA
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171864
• 关键词: Adult; Allografting; Computer Retrieval of Information on Scientific Projects Database; Disease Progression; Distress; Funding; Genomics; Grant; Human; Immunosuppressive Agents; Institution; Kidney; Kidney Diseases; Kidney Transplantation; Pharmaceutical Preparations; Play; Research; Research Personnel; Resources; Role; Source; Structure; Tissues; Transplant Recipients; United States National Institutes of Health; Viral; Virus; kidney allograft

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polymavirus is latent in the kidney of up to 50% of healthy adults. In kidney transplant patients maintained on immunosuppressive drugs, reactivation of virus can result in polymovirus allograft nephropathy (PVAN). PVAN is an inadequately studied and distressing condidtion that frequently leads to graft loss. The study being proposed explores the notion that changes in viral genomic structure might play an important role in the initiation and subsequent progression of this disease

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 多达50％的健康成年人的肾脏潜在多发性肾脏。在维持免疫抑制药物的肾脏移植患者中，病毒的重新激活会导致多个同种异体移植肾病（PVAN）。 PVAN是一种经常导致移植物损失的研究和令人痛苦的凝结。提出的研究探讨了病毒基因组结构变化的观念可能在该疾病的开始和后续进展中起重要作用