POLYMAVIRUS IN HUMAN RENAL ALLOGRAFT TISSUE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 多瘤病毒潜伏在高达50%的健康成人的肾脏中。在维持免疫抑制药物的肾移植患者中，病毒的再活化可导致多形病毒移植物肾病（PVAN）。PVAN是一种研究不足且令人痛苦的疾病，经常导致移植物丢失。这项研究提出了病毒基因组结构的变化可能在这种疾病的发生和随后的进展中起重要作用的概念

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polymavirus is latent in the kidney of up to 50% of healthy adults. In kidney transplant patients maintained on immunosuppressive drugs, reactivation of virus can result in polymovirus allograft nephropathy (PVAN). PVAN is an inadequately studied and distressing condidtion that frequently leads to graft loss. The study being proposed explores the notion that changes in viral genomic structure might play an important role in the initiation and subsequent progression of this disease