Immune Response to Polyomavirus Infection

对多瘤病毒感染的免疫反应

• 批准号: 7095620
• 负责人: PARMJEET S RANDHAWA
• 金额: $ 40.8万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7095620
• 关键词: Polyomavirus; antibody; antigens; clinical research; cytokine; immune response; immunosuppressive; infection; kidney; liver; tissues

DESCRIPTION (provided by applicant): Polyomavirus BK nephropathy is an increasingly recognized complication of organ transplantation. It is associated with significant morbidity & 20-50% risk of graft loss. We propose to study how the immune system reacts to BK virus infection. The ultimate long-term goal of our proposal is to generate data, which will help in the development of vaccines & immunotherapy protocols against this disease. The study will have the following specific aims: (1) To determine the influence of donor and host recipient serologic status on the clinical course of BK virus infection after liver and kidney transplantation. (2) To characterize the anti-BKV T-helper (Th) response in BK virus infection in (a) healthy subjects, (b) kidney transplant recipients, and (c) liver transplant recipients (3) To characterize the T-cytotoxic cell response to BK virus in (a) healthy subjects, (b) kidney transplant recipients, and (c) liver transplant recipients. The information generated during the course of this study will permit earlier diagnosis of BK virus infection, prior to advanced and potentially irreversible tissue injury. The research proposed will also promote better understanding of the biologic factors that initiate and perpetuate viral nephropathy. This, in turn, will help us to better predict the clinical course of the disease in individual patients, and help devise more effective forms of anti-viral therapy.

描述(申请人提供)：多瘤病毒BK肾病是器官移植的一种日益公认的并发症。它与严重的发病率有关&移植物丢失的风险为20%-50%。我们建议研究免疫系统对BK病毒感染的反应。我们建议的最终长期目标是产生数据，这将有助于开发针对这种疾病的疫苗和免疫治疗方案。本研究将有以下具体目的：(1)确定供体和受体的血清学状态对肝肾移植后BK病毒感染临床病程的影响。(2)研究(A)健康人、(B)肾移植受者和(C)肝移植受者对BK病毒感染的抗BKV辅助性T细胞(Th)应答；(3)研究(A)健康人、(B)肾移植受者和(C)肝移植受者对BK病毒的T细胞毒反应。在这项研究过程中产生的信息将使BK病毒感染的早期诊断成为可能，在晚期和潜在的不可逆转的组织损伤之前。这项拟议的研究还将促进人们更好地理解引发和延续病毒性肾病的生物因素。反过来，这将有助于我们更好地预测个别患者的临床病程，并有助于设计出更有效的抗病毒治疗形式。