PATHWAYS OF CONFORMATIONAL TRANSITIONS CRUCIAL FOR SIGNALING, ENZYME CATALYSIS
对信号传导、酶催化至关重要的构象转变途径
基本信息
- 批准号:8171928
- 负责人:
- 金额:$ 0.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-08-01 至 2013-07-31
- 项目状态:已结题
- 来源:
- 关键词:AwardBiological ProcessCatalysisComputer Retrieval of Information on Scientific Projects DatabaseEnzymesFundingGoalsGrantInstitutesInstitutionInvestigationMedicalModelingMolecularPathway interactionsProteinsResearchResearch PersonnelResourcesSignal TransductionSignaling ProteinSourceSystemUnited States National Institutes of HealthWorkconformational conversionconformerprotein protein interactionresearch study
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
We propose a detailed investigation of the mechanism of conformational transition for three diverse proteins representing a signaling protein, an enzyme and a regulator through protein/protein interaction. Recent experiments conducted within our group on these three systems have shown that their ability of interconverting between different coexisting conformers is key to the accomplishment of their biological function. The goal of our investigations is to quantitatively model these conformational changes, and to understand at a molecular level the specific interactions most relevant in triggering and accompanying the interconversions. The proposed work is funded by the Dept of Energy (Award No. DE-FG02-05ER15699) and the Howard Hughes Medical Institute.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DOROTHEE KERN其他文献
DOROTHEE KERN的其他文献
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{{ truncateString('DOROTHEE KERN', 18)}}的其他基金
PATHWAYS OF CONFORMATIONAL TRANSITIONS CRUCIAL FOR SIGNALING, ENZYME CATALYSIS
对信号传导、酶催化至关重要的构象转变途径
- 批准号:
8364312 - 财政年份:2011
- 资助金额:
$ 0.11万 - 项目类别:
TRANSITION PATHWAY OF NITROGEN REGULATORY PROTEIN C (NTRC)
氮调节蛋白 C (NTRC) 的转变途径
- 批准号:
8171908 - 财政年份:2010
- 资助金额:
$ 0.11万 - 项目类别:
TRANSITION PATHWAY OF NITROGEN REGULATORY PROTEIN C (NTRC)
氮调节蛋白 C (NTRC) 的转变途径
- 批准号:
7956369 - 财政年份:2009
- 资助金额:
$ 0.11万 - 项目类别:
TRIPLE RESONANCE CRYOPROBE SYSTEM FOR A 600 MHZ NMR: BIOCHEMISTRY
用于 600 MHZ NMR 的三重共振冷冻探针系统:生物化学
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6973357 - 财政年份:2004
- 资助金额:
$ 0.11万 - 项目类别:
Triple Resonance Cryoprobe System for a 600 MHz NMR
用于 600 MHz NMR 的三重共振冷冻探针系统
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6736501 - 财政年份:2004
- 资助金额:
$ 0.11万 - 项目类别:
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