THE ROLE OF ANATOMICAL STRUCTURE IN VENTRICULAR AND ATRIAL ARRHYTHMIAS

解剖结构在室性和房性心律失常中的作用

• 批准号: 8171823
• 负责人: Elizabeth M Cherry
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171823
• 关键词: Algorithms; Arrhythmia; Atrial Fibrillation; Basic Science; Blood Vessels; Cardiac; Cardiovascular Diseases; Cause of Death; Computer Retrieval of Information on Scientific Projects Database; Computer Simulation; Evolution; Fiber; Funding; Grant; Heart; Heart Atrium; Heart Diseases; Institution; Prevalence; Property; Research; Research Personnel; Resources; Role; Shock; Signal Transduction; Source; Structure; System; Time; Tissues; United States National Institutes of Health; Ventricular; economic impact; health economics; models and simulation; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular disease is the most common cause of death in the industrialized world, with serious health and economic impacts. Two of the most significant forms of heart disease are ventricular and atrial fibrillation. In these arrhythmias, the normal electrical signal responsible for initiating coordinated contraction of the atria or ventricles becomes disrupted. Despite the seriousness and prevalence of cardiac fibrillation, treatment at this time is, in general, unsatisfactory, due to an incomplete understanding of how fibrillation develops and becomes sustained in the context of normal and diseased hearts. Modeling and simulation of cardiac dynamics has become an important tool for analyzing mechanisms that initiate and maintain fibrillation. Over the past several years, we have developed a set of robust computational models to perform basic research on the initiation and evolution of arrhythmias as a function of electrophysiological and anatomical properties. In this proposal we outline our plans to study important open questions, including the mechanisms for alternans in tissue; electrical control algorithms; the role of the specialized ventricular conduction system (Purkinje network) during arrhythmias; the effect of conductivity discontinuities via fiber orientation and inexcitable blood vessels on the initiation and termination of arrhythmias during electric shocks; and mechano-sensitive contributions to arrhythmogenesis.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 心血管疾病是工业化世界中最常见的死亡原因，具有严重的健康和经济影响。心脏病的两种最重要的形式是心室和心房颤动。在这些心律不齐中，负责启动心房或心室协调收缩的正常电信号被破坏。尽管心脏纤维化的严重性和普遍性，但由于对纤颤的发展方式不完全理解，目前的治疗通常是不令人满意的，这是在正常和患病的心脏中的发展。心脏动力学的建模和模拟已成为分析启动和维持纤颤的机制的重要工具。在过去的几年中，我们开发了一组健壮的计算模型，以对心律不齐的启动和演变进行基础研究，这是电生理和解剖学特性的函数。在此提案中，我们概述了研究重要的开放问题的计划，包括组织中替代品的机制；电控制算法；心律不齐期间专门的心室传导系统（Purkinje网络）的作用；电导率通过纤维取向和不可阻碍的血管不连续性对电击期间心律不齐的起始和终止的影响；对心律失常的贡献和机械敏感的贡献。