Computer-guided designer ablation of atrial fibrillation

计算机引导的心房颤动设计师消融术

• 批准号: 6648296
• 负责人: Elizabeth M Cherry
• 金额: $ 4.64万
• 依托单位: HOFSTRA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6648296
• 关键词: arrhythmia; atrial fibrillation; clinical research; computer simulation; diagnostic catheterization; epicardial mapping; heart catheterization; heart conduction system; heart electrical activity; human data; mathematical model; postdoctoral investigator

DESCRIPTION (provided by applicant): Catheter ablation techniques to treat chronic reentrant atrial fibrillation (AF) have been largely unsuccessful. We postulate that a major determinant of failure is the extreme variability in atrial structure among patients, so that no single catheter ablation strategy will be successful; rather, therapy must be individualized for a given patient. We hypothesize that incorporating specific anatomic information about an individual patient's atrial structure into the ablation strategy will increase the likelihood of success. In this project, we propose to perform the fundamental research necessary to bring patient-specific ablation therapy to the animal laboratory and, ultimately, to human patients. Using three-dimensional endocardial mapping techniques during electrophysiologic diagnostic studies, patient-specific atrial anatomy will be reconstructed from data sets containing the locations and electrogram characteristics of atrial points obtained by a catheter probe. Simulations of AF will be performed using the reconstructed atria. Within this framework, different ablation strategies will be tested in silico to determine how ablation lesions can be successfully performed for each specific individual anatomic structure. This work is designed to lead directly to testable ablation strategies and to novel clinical paradigms in the treatment of AF.

描述（由申请人提供）：治疗慢性重入房颤（AF）的导管消融技术在很大程度上没有成功。我们假设，失败的主要决定因素是患者心房结构的极端变异性，因此没有任何单个导管消融策略将成功。相反，必须为给定患者个性化治疗。我们假设将有关个体患者的心房结构的特定解剖信息纳入消融策略将增加成功的可能性。在这个项目中，我们建议进行必要的基础研究，以将患者特异性消融疗法带到动物实验室，并最终向人类患者带来。在电生理诊断研究期间，将使用三维心室映射技术，将从包含包含导管探针获得的心房点的位置和电位特征的数据集中重建患者特异性心房解剖结构。 AF的模拟将使用重建的心房进行。在此框架内，将在计算机中测试不同的消融策略，以确定如何成功地为每个特定的单个解剖结构执行消融病变。这项工作旨在直接导致可测试的消融策略和新的AF治疗临床范例。