SPECIFICITY OF TRAINING: CORTICAL ACTIVATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在之前的一项使用正电子发射断层扫描（PET）的研究中，Sadato N、Pascual-Leone A、Grafman J等人1发现，在盲人受试者中，视觉皮层与使用食指的触觉任务有关，但在视力正常的受试者中则不然。在一项测量空间分辨率极限的类似研究中，货车Boven RW、汉密尔顿RH、考夫曼T2等人发现，盲人与视力正常者相比，在优势盲文阅读手指触觉任务中，空间敏锐度阈值低于中指。使用功能性磁共振成像（fMRI）和触觉辨别任务，我们想进一步探索在第一项研究中发现的相同大脑组织是否存在于相邻的非盲文阅读手指。这将解决大脑组织的特异性以及大脑如何适应影响感官的条件，如早期失明。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In a previous study using positron emission tomography (PET), Sadato N, Pascual-Leone A, Grafman J et al1 revealed that the visual cortex was involved with tactile tasks using the index finger in subjects who were blind, but not those who were sighted. In a similar study measuring spatial resolution limits, Van Boven RW, Hamilton RH, Kaufmann T2 et al found lower spatial acuity threshold in a dominant Braille reading finger tactile task versus the middle finger for those who were blind versus those who were sighted. Using functional Magnetic Resonance Imaging (fMRI) and a tactile discrimination task, we would like to further explore whether the same brain organization found in the first study exists for the adjacent, non-Braille reading finger. This will address specificity in brain organization and how the brain adapts to conditions that influence the senses, such as early blindness.