SPECIFICITY OF TRAINING: CORTICAL ACTIVATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在之前的一项使用正电子发射断层扫描(PET)的研究中，Sadato N，Pascual-Leone A，Grafman J等人发现，在盲人受试者中，视觉皮质参与了使用食指进行的触觉任务，而视力正常的受试者则没有。在一项测量空间分辨率极限的类似研究中，Van Boven RW，Hamilton RH，Kaufmann T2等人发现，盲人与有视力的人相比，在主导盲文阅读手指触觉任务中，空间敏锐度阈值较低。利用功能磁共振成像(FMRI)和触觉辨别任务，我们想进一步探索第一项研究中发现的相同的大脑组织是否存在于相邻的非盲文阅读手指上。这将解决大脑组织的特殊性，以及大脑如何适应影响感官的条件，如早期失明。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In a previous study using positron emission tomography (PET), Sadato N, Pascual-Leone A, Grafman J et al1 revealed that the visual cortex was involved with tactile tasks using the index finger in subjects who were blind, but not those who were sighted. In a similar study measuring spatial resolution limits, Van Boven RW, Hamilton RH, Kaufmann T2 et al found lower spatial acuity threshold in a dominant Braille reading finger tactile task versus the middle finger for those who were blind versus those who were sighted. Using functional Magnetic Resonance Imaging (fMRI) and a tactile discrimination task, we would like to further explore whether the same brain organization found in the first study exists for the adjacent, non-Braille reading finger. This will address specificity in brain organization and how the brain adapts to conditions that influence the senses, such as early blindness.