FMRI ANALYSIS OF ANKLE MOVEMENT TRACKING TRAINING IN SUBJECTS WITH STROKE

中风受试者踝关节运动跟踪训练的 FMRI 分析

• 批准号: 7601622
• 负责人: JAMES R. CAREY
• 金额: $ 5.9万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601622
• 关键词: Ankle; Area; Articular Range of Motion; Brain; Computer Retrieval of Information on Scientific Projects Database; Computers; Count; Data; Failure; Floor; Funding; Gait; Grant; Imagery; Institution; Magnetic Resonance; Measurement; Measures; Motion; Movement; Parietal Lobe; Patient Self-Report; Phase; Range of motion exercise; Rate; Research; Research Personnel; Resources; Signal Transduction; Source; Standards of Weights and Measures; Stroke; Testing; Time; Toes; Training; United States National Institutes of Health; Visual; Walking; follow-up; foot; improved; indexing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study examined whether ankle-movement tracking training could improve ankle function and brain reorganization, evidenced with functional magnetic resonance imagery (fMRI), in a single subject with stroke. Test measurements included self-ratings of functional activities, 15.24 m (50 feet) walk time, ankle range of motion, ankle tracking accuracy, and peak dorsiflexion movement during dorsiflexion phases of tracking. Cortical activation in the frontal and parietal lobes was measured during fMRI with an active voxel count. Additionally, a signal intensity index was determined for the gyrus precentralis (GPrC). Training consisted of 16 sessions of tracking waveforms on a computer screen with ankle motion. Four pretest, four posttest and two follow-up measurements occurred. Data were analyzed by visual inspection and by statistical analysis that examined whether posttest measurements exceeded the pretest mean by at least two standard deviations on at least two consecutive posttest measurements. Posttest results showed that the subject's self report of paretic ankle "catches" (failure of toes to clear floor during swing phase) during gait were eliminated and that peak dorsiflexion movement improved visually but not statistically. Multiple cortical areas showed increased voxel count statistically, as did the intensity index for GPrC. Follow-up results showed that the ankle "catches", peak dorsiflexion movement, and the intensity index remained at the same levels as posttest. Voxel counts returned toward pretest values. We concluded that tracking training produced training effects in both ankle function and brain reorganization.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究通过功能性磁共振成像(FMRI)研究了踝关节运动跟踪训练是否能改善中风患者的踝关节功能和脑重组。测试测量包括功能活动自我评级，15.24米(50英尺)步行时间，踝关节活动范围，脚踝跟踪准确性，以及跟踪背屈阶段的最大背屈运动。额叶和顶叶的皮质激活在功能磁共振成像中被测量，并进行活跃的体素计数。此外，还测定了中央前回(GPrC)的信号强度指数。训练包括在电脑屏幕上跟踪16次带有脚踝运动的波形。进行了四次前测、四次后测和两次跟踪测量。通过目视检查和统计分析对数据进行分析，这些统计分析检查了在至少两个连续的后测测量中，后测测量是否超过前测平均值至少两个标准差。后测结果显示，受试者在步态过程中自我报告的偏瘫脚踝“卡住”(摆动阶段脚趾未能清理地板)的情况被消除，峰值背屈运动在视觉上有所改善，但没有统计学意义。多个皮质区域在统计学上显示体素计数增加，GPrC的强度指数也是如此。随访结果显示，踝关节“接住”，峰值背屈运动，强度指数保持在测试后的水平。体素计数返回到预测值。我们的结论是，跟踪训练在踝关节功能和脑重组方面都产生了训练效果。