TRAINING IN FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY

傅里叶变换离子回旋共振质谱培训

• 批准号: 8170885
• 负责人: CHI-WEI LIN
• 金额: $ 0.58万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170885
• 关键词: Biochemistry; Bioinformatics; Boston; Carbohydrates; Chemistry; Collaborations; Computer Retrieval of Information on Scientific Projects Database; England; Fourier Transform; Fourier transform ion cyclotron resonance; Funding; Grant; HRAS gene; Human; Institution; Left; Mass Spectrum Analysis; Medicine; Modification; Oxidative Stress; Peptides; Positioning Attribute; Postdoctoral Fellow; Research; Research Personnel; Research Project Grants; Resources; SHFM1 gene; Scientist; Source; Techniques; Training; United States National Institutes of Health; Universities; Washington; Work; base; graduate student; instrument; medical schools; meetings; professor; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. One of the objectives of this program is to train new graduate students and professional scientific researchers in new techniques. One such technique which we have focused on is Fourier transform mass spectrometry. Since the departure of Dr. Peter O'Connor in Jan 2009 to become a tenured full professor in the Department of Chemistry at the University of Warwick, Coventry, England, Dr. Cheng Lin has assumed responsibility for training in FTMS, and FTMS-based research projects. He is now a research assistant professor in the Department of Biochemistry at Boston University School of Medicine, and the Assistant Director of the Resource. A graduate student from the FTMS research group, Konstantine Aizikov, defended his Ph. D. thesis in November 2009, and remains at the MSR as a postdoctoral associate working on glyco-bioinformatics. A former postdoc, Dr. Weidong Cui left in May 2009 to take a staff scientist position at Washington University in St. Louis. In September 2009, Yuhuan Ji joined the FTMS group as a graduate student, working on human H-ras modifications under oxidative stress, in collaboration with Dr. Cohen's group in the Department of Medicine. In December 2009, Dr. Yiqun Huang joined the FTMS group as a postdoctoral fellow, taking on the mechanistic studies of ECD of peptides and carbohydrates. In January 2010, the newly arrived 12 T Bruker solariX FT-ICR instrument, acquired through a high-end shared instrument grant, was certified to meet all specs in January 2010. Since then, several postdoctoral research associates of the Resource and senior graduate students from the FTMS group have been properly trained to use this new instrument for a diversity of research projects.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该计划的目标之一是培养新的研究生和新技术的专业科学研究人员。 我们所关注的一种这样的技术是傅立叶变换质谱法。 自2009年1月Peter奥康纳博士离职成为英国考文垂沃里克大学化学系终身教授以来，Cheng Lin博士负责FTMS培训和基于FTMS的研究项目。他现在是波士顿大学医学院生物化学系的研究助理教授，也是资源部的助理主任。 FTMS研究小组的一名研究生康斯坦丁·艾齐科夫（Konstantine Aizikov）为自己的博士学位辩护。他于2009年11月完成了博士论文，并作为博士后研究员继续在MSR从事糖生物信息学工作。 作为一名前博士后，崔卫东博士于2009年5月离开，在圣路易斯的华盛顿大学担任科学家。 2009年9月，Yuhuan Ji作为研究生加入FTMS小组，与医学系的Cohen博士小组合作，研究氧化应激下的人类H-ras修饰。2009年12月，黄益群博士以博士后身份加入FTMS研究组，从事多肽和碳水化合物的ECD机理研究。 2010年1月，通过高端共享仪器赠款购买的12 T布鲁克solariX FT-ICR仪器在2010年1月通过认证，符合所有规格。从那时起，几个博士后研究助理的资源和高年级研究生从FTMS组已得到适当的培训，使用这种新的工具的多样性的研究项目。