NONINVASIVE QUANTITATION OF BIOCHEM CHANGESPARKINSONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 帕金森病患者黑质生化变化的非侵入性定量(与神经病学Paul Tuite博士合作，由Dana基金会支持)：该项目的目标是通过高场MRS测量帕金森病患者黑质的神经化学变化。黑质是主要受帕金森氏病影响的大脑区域，MRS在该区域检测到的神经化学变化可能作为生物标志物以及提高我们对疾病机制的理解。然而，由于黑质结构的小尺寸和含铁量，MRS是非常具有挑战性的。我们在4特斯拉扫描仪上的初步数据已经证明了量化患者和对照中的10种神经化学物质的可行性，以及一些神经化学物质在患者中的变化趋势。我们在这个项目中的目标是将光谱方法转移到我们的7特斯拉扫描仪上，以提高灵敏度，并能够更好地定位黑质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Noninvasive Quantitation of Biochemical Changes in the Human Substantia Nigra in Parkinson's Disease (in collaboration with Dr. Paul Tuite, Neurology, supported by Dana Foundation): The goal in this project is to measure neurochemical alterations by high field MRS in the substantia nigra of patients with Parkinson's disease. Substantia nigra is the brain region primarily affected by Parkinson's disease and neurochemical alterations detected by MRS in this region may be utilized as biomarkers as well as improve our understanding of disease mechanisms. However, MRS of substantia nigra is very challenging due to the small size and iron content of the structure. Our preliminary data at a 4 Tesla scanner has demonstrated the feasibility of quantifying 10 neurochemicals in patients and controls and trends for some neurochemicals to change in patients. Our goal in this project was to move the spectroscopy methods to our 7 Tesla scanner in order to improve sensitivity and to be able to localize better in the substantia nigra.