NONINVASIVE QUANTITATION OF BIOCHEM CHANGESPARKINSONS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 帕金森病患者黑质生化变化的非侵入性定量（与Dana基金会支持的神经病学Paul Tuite博士合作）：该项目的目标是通过高场MRS测量帕金森病患者黑质的神经化学变化。 黑质是主要受帕金森病影响的脑区，MRS在该区域检测到的神经化学改变可用作生物标志物，并提高我们对疾病机制的理解。然而，由于黑质结构的小尺寸和铁含量，MRS非常具有挑战性。我们在4特斯拉扫描仪上的初步数据已经证明了量化患者和对照中的10种神经化学物质的可行性，以及患者中某些神经化学物质的变化趋势。 我们在这个项目中的目标是将光谱学方法转移到我们的7特斯拉扫描仪上，以提高灵敏度，并能够更好地定位在黑质中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Noninvasive Quantitation of Biochemical Changes in the Human Substantia Nigra in Parkinson's Disease (in collaboration with Dr. Paul Tuite, Neurology, supported by Dana Foundation): The goal in this project is to measure neurochemical alterations by high field MRS in the substantia nigra of patients with Parkinson's disease. Substantia nigra is the brain region primarily affected by Parkinson's disease and neurochemical alterations detected by MRS in this region may be utilized as biomarkers as well as improve our understanding of disease mechanisms. However, MRS of substantia nigra is very challenging due to the small size and iron content of the structure. Our preliminary data at a 4 Tesla scanner has demonstrated the feasibility of quantifying 10 neurochemicals in patients and controls and trends for some neurochemicals to change in patients. Our goal in this project was to move the spectroscopy methods to our 7 Tesla scanner in order to improve sensitivity and to be able to localize better in the substantia nigra.