COASSEMBLY OF TWO CHARGEABLE BLOCK COPOLYMERS INTO MULTICOMPARTMENT MICELLES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 嵌段共聚物丰富的化学性质使得嵌段共聚物能够自组装形成丰富的聚合物结构，这些聚合物结构在纳米技术中有着广泛的应用。然而，嵌段共聚物的化学性质的操作需要仔细的设计和繁琐的化学合成。在这里，我们介绍了一种新的组装策略的嵌段共聚物在溶液状态下，以实现所需的纳米结构在一个简单的方式。该范例涉及两种或更多种嵌段共聚物的混合物，所述嵌段共聚物共享带负电荷的亲水性羧酸嵌段但化学上不相容的疏水性嵌段。在与带正电荷的氨基分子的水性混合物中组装期间，由于胶束核心内的疏水嵌段的分离，已经获得了不同的独特的纳米结构，例如多层囊泡、Janus扁球形纳米颗粒和波状圆柱形胶束。该过程经历了由快速胶束内聚合物链重组以及溶液中单个胶束之间聚合物链交换的缓慢动力学确定的形态转化途径。同步加速器SAXS配备了高通量和高分辨率的光束线，已被我们以前的实验证明是一个强大的全球性，实时表征方法，以确定组装结构在其原始溶液条件下。对组装途径的完整理解使我们能够为新型聚合物纳米结构开发新的组装策略

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The wealth in chemistry of block copolymers allows the self assembly of block copolymer to result in abundant polymeric structures which find wide applications in nanotechnology. However, the manipulation of the chemistry of block copolymers requires careful design and tedious chemical synthesis. Herein we introduce a new assembly strategy of block copolymers in the solution state to achieve desired nanostructures in a simple manner. This paradigm involves a mixture of two or more block copolymers sharing a negatively chargeable hydrophilic carboxylic acid block but chemically incompatible hydrophobic blocks. During assembly in the aqueous mixture with positively charged amino molecules, different unique nanostructures, such as multilayer vesicles, Janus oblate nanoparticles and undulated cylindrical micelles, have been obtained due to the segregation of hydrophobic blocks within the micellar core. This process undergoes a pathway of morphological transformations determined by fast intra-micellar polymer chain reorganization as well as slow kinetics of polymeric chain exchange between individual micelles in solution. Synchrotron SAXS equipped with a beamline of high flux and high resolution has been proved by our previous experiments as a powerful global, real-time characterization method to identify the assembled structures under their original solution conditions. A complete understanding of assembly pathways enables us to develop new assembly strategies for novel polymeric nanostructures