HIGH RESOLUTION FIBER CRYSTALLOGRAPHY ON 14 BM-C

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 就在这个赠款周期开始之前，我们与APS的另一个P41研究资源BioCARS建立了一项合作安排，以运行一个光纤衍射计划14BM-C。其中一个动机是需要进行生物安全2或3实验，另一个动机是扩大波束时间和机会，以在既定核心之外发展用户社区。我们的一些用户有时需要收集非常高分辨率的数据，这是使用非常大格式的晶体探测器(如14 BM-C的ADSC Quantum 310)所能做到的。我们现在拥有稳定和成熟的用户群，他们能够在他们的项目中出色地使用14BM-C，而更具技术挑战性的光纤衍射项目继续使用18ID。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A little before the beginning of this grant cycle we established a collaborative arrangement with BioCARS, another P41 Research Resource at the APS, to run a fiber diffraction program 14BM-C. One of the motivations is the need to perform Biosafety 2 or 3 experiments, another being the expanded beamtime and opportunities to grow the user community beyond the established core. Some of our users needed, on occasion, to collect very high-resolution data that is possible with very large format crystallography detectors such as the ADSC Quantum 310 at 14 BM-C. We now have a regular and maturing user base that are able to make excellent use of 14BM-C for their projects while more technically challenging fiber diffraction projects continue on 18ID.