HIGH RESOLUTION FIBER CRYSTALLOGRAPHY ON 14 BM-C

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在本资助周期开始前不久，我们与APS的另一个P41研究资源BioCARS建立了合作安排，以运行纤维衍射程序14 BM-C。动机之一是需要进行生物安全2或3实验，另一个是扩大射束时间和扩大用户社区的机会。 我们的一些用户有时需要收集非常高分辨率的数据，这可以通过非常大格式的晶体学探测器来实现，例如ADSC Quantum 310在14 BM-C。 我们现在有一个固定和成熟的用户群，能够在他们的项目中充分利用14 BM-C，同时在18 ID上继续进行更具技术挑战性的光纤衍射项目。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A little before the beginning of this grant cycle we established a collaborative arrangement with BioCARS, another P41 Research Resource at the APS, to run a fiber diffraction program 14BM-C. One of the motivations is the need to perform Biosafety 2 or 3 experiments, another being the expanded beamtime and opportunities to grow the user community beyond the established core. Some of our users needed, on occasion, to collect very high-resolution data that is possible with very large format crystallography detectors such as the ADSC Quantum 310 at 14 BM-C. We now have a regular and maturing user base that are able to make excellent use of 14BM-C for their projects while more technically challenging fiber diffraction projects continue on 18ID.