MICRO WIDE ANGLE FIBER DIFFRACTION DEVELOPMENT AND CHARACTERIZATION
微广角光纤衍射开发和表征
基本信息
- 批准号:7722779
- 负责人:
- 金额:$ 3.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-04-01 至 2008-12-31
- 项目状态:已结题
- 来源:
- 关键词:AmyloidBiologicalCollagenComputer Retrieval of Information on Scientific Projects DatabaseCrystallographyDataDevelopmentEquipmentFiberFundingGrantHelix (Snails)InstitutionNeurologicRadiationRangeResearchResearch PersonnelResolutionResourcesRoentgen RaysSamplingSourceSpottingsTimeTissuesUnited States National Institutes of HealthWaxesear helixinstrumentpreventsizetau Proteins
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
One of the core projects in the current grant cycle is the development of a flexible, high flux instrument for micro-diffraction of small ordered domains in biological materials with emphasis on studies of connective and neurological tissue. The micro-diffraction capabilities should meet the following requirements: For wide angle: d-space range 200-3.0 ¿ to resolve amyloid cross-beta signatures and higher harmonics of any features from super-helices. For small angle a d-space range of 800-100 ¿ to resolve first order of collagen (670) with overlap with WAX data for merging of low and high angle data and resolution of Tau fiber helical twist (~800 ¿). The focal spot sizes, on the sample, need to be less than 10 microns (preferably much less) in each direction. Use of cryo-crystallography equipment will be extremely important for the micro-diffraction modes, to prevent radiation damage in the sample while exposed to the X-ray beam over extended periods of time.
这个子项目是许多利用
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
中心,但不一定是研究者所在的机构。
本赠款周期的核心项目之一是开发一种灵活的高通量仪器,用于生物材料中小有序域的微衍射,重点是结缔组织和神经组织的研究。微衍射能力应满足以下要求:对于广角:d-空间范围200-3.0?,以解析淀粉样蛋白交叉β特征和来自超螺旋的任何特征的高次谐波。对于小角度,d空间范围为800-100,以解析胶原蛋白的第一级(670),与WAX数据重叠,以合并低角度和高角度数据,并解析Tau纤维螺旋扭曲(~800)。样品上的焦斑尺寸在每个方向上需要小于10微米(优选地小得多)。使用低温结晶设备对于微衍射模式将是极其重要的,以防止样品在长时间暴露于X射线束时受到辐射损伤。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Joseph Patrick Rosen O'Dubhthaigh Orgel其他文献
Joseph Patrick Rosen O'Dubhthaigh Orgel的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Joseph Patrick Rosen O'Dubhthaigh Orgel', 18)}}的其他基金
THE MOLECULAR STRUCTURE OF COLLAGEN TYPES I AND II
I 型和 II 型胶原蛋白的分子结构
- 批准号:
8361271 - 财政年份:2011
- 资助金额:
$ 3.16万 - 项目类别:
HIGH RESOLUTION FIBER CRYSTALLOGRAPHY ON 14 BM-C
14 BM-C 上的高分辨率光纤晶体学
- 批准号:
8168663 - 财政年份:2010
- 资助金额:
$ 3.16万 - 项目类别:
THE MOLECULAR STRUCTURE OF COLLAGEN TYPES I AND II
I 型和 II 型胶原蛋白的分子结构
- 批准号:
8168617 - 财政年份:2010
- 资助金额:
$ 3.16万 - 项目类别:
FEASIBILITY TESTS FOR WIDE ANGLE FIBER DIFFRACTION STUDIES ON 14 BM-C
14 BM-C 广角光纤衍射研究的可行性测试
- 批准号:
7956803 - 财政年份:2009
- 资助金额:
$ 3.16万 - 项目类别:
THE MOLECULAR STRUCTURE OF COLLAGEN TYPES I AND II
I 型和 II 型胶原蛋白的分子结构
- 批准号:
7954899 - 财政年份:2009
- 资助金额:
$ 3.16万 - 项目类别:
FEASIBILITY TESTS FOR WIDE ANGLE FIBER DIFFRACTION STUDIES ON 14 BM-C
14 BM-C 广角光纤衍射研究的可行性测试
- 批准号:
7956838 - 财政年份:2009
- 资助金额:
$ 3.16万 - 项目类别:
FEASIBILITY TESTS FOR WIDE ANGLE FIBER DIFFRACTION STUDIES ON 14 BM-C
14 BM-C 广角光纤衍射研究的可行性测试
- 批准号:
7726016 - 财政年份:2008
- 资助金额:
$ 3.16万 - 项目类别:
THE MOLECULAR STRUCTURE OF COLLAGEN TYPES I AND II
I 型和 II 型胶原蛋白的分子结构
- 批准号:
7722752 - 财政年份:2008
- 资助金额:
$ 3.16万 - 项目类别:
相似海外基金
Effects of the mechanical interactions between collagen molecules on the mechanical adaptation of biological tissues
胶原分子之间的机械相互作用对生物组织机械适应的影响
- 批准号:
26350519 - 财政年份:2014
- 资助金额:
$ 3.16万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Early glycation products of collagen: a solid-state NMR spectrscopy and ultrastructural study of biological and health implications
胶原蛋白的早期糖化产物:生物和健康影响的固态核磁共振波谱和超微结构研究
- 批准号:
MR/J007692/1 - 财政年份:2013
- 资助金额:
$ 3.16万 - 项目类别:
Research Grant
Imaging the 3-D collagen organisation of biological tissues in-vivo using polarisation-sensitive optical coherence tomography.
使用偏振敏感光学相干断层扫描对体内生物组织的 3D 胶原蛋白组织进行成像。
- 批准号:
EP/F020422/1 - 财政年份:2008
- 资助金额:
$ 3.16万 - 项目类别:
Research Grant
Effects of the mechanical relationships between collagen fibrils and ground substances on the mechanical adaptation of biological tissues
胶原纤维和基质之间的机械关系对生物组织机械适应的影响
- 批准号:
20560092 - 财政年份:2008
- 资助金额:
$ 3.16万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Biomechanics on Remodeling of Biological Tissues - Role of Collagen Cross-Linking
生物组织重塑的生物力学——胶原蛋白交联的作用
- 批准号:
18500354 - 财政年份:2006
- 资助金额:
$ 3.16万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
SGER: Development of a Collagen "Nanoloom" for the Generation of 2 and 3 Dimensional Biological Templates for Tissue Engineering
SGER:开发胶原蛋白“Nanoloom”,用于生成组织工程的 2 维和 3 维生物模板
- 批准号:
0541707 - 财政年份:2005
- 资助金额:
$ 3.16万 - 项目类别:
Standard Grant
Characterization of the structure and biological role of Streptococcus intermedius fibronectin and collagen binding adhesins
中间链球菌纤连蛋白和胶原结合粘附素的结构和生物学作用的表征
- 批准号:
5330680 - 财政年份:2001
- 资助金额:
$ 3.16万 - 项目类别:
Research Grants
Biological Function of Type VIII Collagen
VIII 型胶原蛋白的生物学功能
- 批准号:
06044154 - 财政年份:1994
- 资助金额:
$ 3.16万 - 项目类别:
Grant-in-Aid for international Scientific Research
BIOLOGICAL RECONSTRUCTION OF PERIODONTAL TISSUE USING CYTOKINE AND FIBROUS COLLAGEN MEMBRANE
使用细胞因子和纤维胶原膜对牙周组织进行生物重建
- 批准号:
04557078 - 财政年份:1992
- 资助金额:
$ 3.16万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
Biological Function of Type VIII Collagen
VIII 型胶原蛋白的生物学功能
- 批准号:
04044124 - 财政年份:1992
- 资助金额:
$ 3.16万 - 项目类别:
Grant-in-Aid for international Scientific Research