VALIDATION OF MRI IMAGES OF THE TONGUE TO STUDY DYSPHAGIA

验证舌头 MRI 图像以研究吞咽困难

• 批准号: 8173115
• 负责人: JOANNE ROBBINS
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173115
• 关键词: Adult; Anatomy; Animals; Anterior; Area; Brain imaging; Child; Clinical; Computer Retrieval of Information on Scientific Projects Database; Deglutition; Deglutition Disorders; Electronics; Functional Magnetic Resonance Imaging; Funding; Grant; Hand; Human; Image; Imaging Techniques; Institution; Magnetic Resonance Imaging; Methods; Modeling; Monkeys; Motor; Muscle; Participant; Primates; Research; Research Design; Research Personnel; Resources; Sensory; Services; Source; Tongue; United States National Institutes of Health; Validation; Work; cingulate cortex; improved; neurophysiology; nonhuman primate; systematic review

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To study swallowing in humans, using a nonhuman primate model, to improve treatments of dysphagia (swallowing problems). About 18 million adults and many more millions of children have swallowing problems in the U.S. This may be due to changes in the tongue, weaker muscles and fewer muscles. We are using a nonhuman primate model to more closely study primate anatomy to explore new avenues to treating dysphagia. We are validating the MRI work we are conducting in humans and monkeys. Unknowns about the neurophysiology of normal and disordered swallowing have stimulated exciting and important research questions. Previously, these questions were answered using clinical and animal studies. However, recent technologic advances have moved brain-imaging techniques such as functional magnetic resonance imaging (fMRI) to the forefront of swallowing neurophysiology research. This systematic review has summarized the methods and results of studies of swallowing neurophysiology of healthy adults using fMRI. A comprehensive electronic and hand search for original research was conducted, including few search limitations to yield the maximum possible number of relevant studies. The participants, study design, tasks, and brain image acquisition were reviewed and the results indicate that the primary motor and sensory areas were most consistently active in the healthy adult participants across the relevant studies. Other prevalent areas of activation included the anterior cingulate cortex and insular cortex. This research used WNPRC Animal Services.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：使用非人灵长类动物模型研究人类的吞咽，以改善吞咽困难（吞咽问题）的治疗。 在美国，大约有1800万成年人和数百万儿童有吞咽问题，这可能是由于舌头的变化、肌肉的减弱和肌肉的减少。我们正在使用一种非人类灵长类动物模型来更仔细地研究灵长类动物的解剖学，以探索治疗吞咽困难的新途径。我们正在验证我们在人类和猴子身上进行的MRI工作。 关于正常和吞咽障碍的神经生理学的未知刺激了令人兴奋和重要的研究问题。以前，这些问题是通过临床和动物研究来回答的。然而，最近的技术进步已经将脑成像技术，如功能性磁共振成像（fMRI），推向了吞咽神经生理学研究的前沿。本文综述了功能磁共振成像对健康成人吞咽神经生理学研究的方法和结果。对原始研究进行了全面的电子和手动搜索，包括很少的搜索限制，以产生最大可能数量的相关研究。对参与者、研究设计、任务和大脑图像采集进行了审查，结果表明，在相关研究中，健康成年参与者的初级运动和感觉区域最活跃。其他常见的激活区域包括前扣带皮层和岛叶皮层。 这项研究使用WNPRC动物服务。