VALIDATION OF MRI IMAGES OF THE TONGUE TO STUDY DYSTHAGIA

验证舌头 MRI 图像以研究吞咽困难

• 批准号: 7716472
• 负责人: JOANNE ROBBINS
• 金额: $ 4.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-23 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716472
• 关键词: Adult; Anatomy; Animals; Anterior; Area; Brain imaging; Child; Clinical; Computer Retrieval of Information on Scientific Projects Database; Deglutition; Deglutition Disorders; Electronics; Functional Magnetic Resonance Imaging; Funding; Grant; Hand; Human; Image; Imaging Techniques; Institution; Magnetic Resonance Imaging; Methods; Modeling; Monkeys; Motor; Muscle; Numbers; Participant; Primates; Research; Research Design; Research Personnel; Resources; Review, Systematic (PT); Sensory; Services; Source; Tongue; United States National Institutes of Health; Validation; Work; cingulate cortex; improved; neurophysiology; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To study swallowing in humans, using a nonhuman primate model, to improve treatments of dysthagia (swallowing problems). About 18 million adults and many more millions of children have swallowing problems in the U.S. This may be due to changes in the tongue, weaker muscles and fewer muscles, so we are using a nonhuman primate model to more closely study primate anatomy to explore new avenues to treating dysthagia. We are validating the MRI work we are doing in humans and monkeys. Unknowns about the neurophysiology of normal and disordered swallowing have stimulated exciting and important research questions. Previously, these questions were answered using clinical and animal studies. However, recent technologic advances have moved brain-imaging techniques such as functional magnetic resonance imaging (fMRI) to the forefront of swallowing neurophysiology research. This systematic review has summarized the methods and results of studies of swallowing neurophysiology of healthy adults using fMRI. A comprehensive electronic and hand search for original research was conducted, including few search limitations to yield the maximum possible number of relevant studies. The participants, study design, tasks, and brain image acquisition were reviewed and the results indicate that the primary motor and sensory areas were most consistently active in the healthy adult participants across the relevant studies. Other prevalent areas of activation included the anterior cingulate cortex and insular cortex. This research uses WNPRC Animal Services.

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