IMMUNE CORRELATES OF PROTECTION AGAINST SIVE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 尽管高效抗逆转录病毒疗法(HAART)得到了广泛应用，但神经系统疾病继续显著增加与艾滋病毒感染相关的发病率和死亡率。预防HIV脑炎(HIVE)的免疫学相关性尚未确定；然而，这一信息对于设计能够安全地抑制病毒在大脑和外周淋巴组织中复制的艾滋病疫苗至关重要。尽管抗病毒抗体在HIV神经发病机制中的具体作用知之甚少，但最近的报道表明，中和抗体(NAB)反应受损的患者患HIV相关痴呆(HAD)的风险可能增加。在这项研究中，我们使用神经毒力SIV/猕猴模型来研究适应性宿主免疫在预防SIV脑炎(SIVE)发展中的作用。该项目的中心假设认为，NAB对于在细胞介导免疫反应不佳的动物中提供防止SIVE发展的附带保护是重要的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the widespread use of highly active antiretroviral therapy (HAART), neurological disorders continue to contribute significantly to the morbidity and mortality associated with HIV infection. The immunological correlates of protection against HIV encephalitis (HIVE) have not been identified; however, this information is critical for designing AIDS vaccines that are capable of safely suppressing viral replication in the brain as well as in peripheral lymphoid tissues. Although little is known about the specific effect of antiviral antibodies on the course of HIV neuropathogenesis, recent reports suggest that patients with impaired neutralizing antibody (NAb) responses may be at increased risk for the development of HIV-associated dementia (HAD). In this research program we are using a neurovirulent SIV/macaque model to investigate the role of adaptive host immunity in providing protection against the development of SIV encephalitis (SIVE). The central hypothesis of this project argues that NAb are important for providing collateral protection against the development of SIVE in animals with suboptimal cell-mediated immune responses.