ESTABLISHING PREDICTORS OF SIB IN RHESUS MONKEYS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们先前已经建立了一种自然发生SIB的动物模型，与对照组相比，猴子显示出减少的应激反应和较低的阿片类药物水平。 由于我们只在猴子自发发生SIB后才对其进行研究，因此我们不知道这些差异是否是发生SIB的风险因素或后果。 本项目的目的是确定是否有SIB和刻板行为发病的早期标志物。 我们目前正在对一组雄性猴子进行一项独特的大规模纵向研究，在这项研究中，我们正在协调我们对异常行为的标准行为评估，收集毛发和唾液样本进行皮质醇和其他测定，并寻找预测后期SIB或刻板症发展的多态性基因变异。 我们还研究了猕猴的毛发皮质醇谱作为住房，早期饲养和物种的函数（与Stephen Suomi博士合作，NICHD）。 这些综合征的生物标志物的测定，然后可以用于菌落筛选和新的预防策略的发展。 阐明SIB的新生物标志物也将对我们理解人类临床人群中的这种疾病具有重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have previously established an animal model of naturally occurring SIB in which monkeys show a reduced stress response and lower opioid levels compared to controls. Because we study monkeys only after they have spontaneously developed SIB, we do not know whether these differences are risk factors for or consequences of developing SIB. The purpose of this project is to determine whether there are early markers for the onset of SIB and stereotypic behavior. We are currently conducting a unique, large-scale longitudinal study of a cohort of male monkeys in which we are coordinating our standard behavioral assessments of abnormal behavior, collecting hair and saliva samples for cortisol and other assays, and searching for polymorphic gene variants that are predictive of later SIB or stereotypy development. We are also examining hair cortisol profiles in macaques as a function of housing, early rearing, and species (in collaboration with Dr. Stephen Suomi, NICHD). The determination of biomarkers for these syndromes can then be used for colony screening and the development of new prevention strategies. Elucidation of novel biomarkers of SIB will also have significant implications for our understanding of this disorder in human clinical populations.