ESTABLISHING PREDICTORS OF SIB IN RHESUS MONKEYS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们之前已经建立了一个自然发生的SIB的动物模型，在该模型中，与对照组相比，猴子的应激反应和阿片类药物水平都有所降低。因为我们只是在猴子自发地发展出SIB之后才进行研究，我们不知道这些差异是否是发展SIB的危险因素或后果。本项目的目的是确定是否存在SIB和刻板印象行为的早期标志物。我们目前正在对一群雄性猴子进行一项独特的、大规模的纵向研究，其中我们正在协调对异常行为的标准行为评估，收集毛发和唾液样本进行皮质醇和其他分析，并寻找可以预测以后SIB或刻板印象发展的多态基因变异。我们还研究了短尾猴的毛发皮质醇分布与住房、早期饲养和物种的关系(与NICHD的Stephen Suomi博士合作)。这些综合征的生物标记物的测定然后可用于群体筛选和开发新的预防策略。阐明SIB的新生物标志物也将对我们理解人类临床人群中的这种疾病具有重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have previously established an animal model of naturally occurring SIB in which monkeys show a reduced stress response and lower opioid levels compared to controls. Because we study monkeys only after they have spontaneously developed SIB, we do not know whether these differences are risk factors for or consequences of developing SIB. The purpose of this project is to determine whether there are early markers for the onset of SIB and stereotypic behavior. We are currently conducting a unique, large-scale longitudinal study of a cohort of male monkeys in which we are coordinating our standard behavioral assessments of abnormal behavior, collecting hair and saliva samples for cortisol and other assays, and searching for polymorphic gene variants that are predictive of later SIB or stereotypy development. We are also examining hair cortisol profiles in macaques as a function of housing, early rearing, and species (in collaboration with Dr. Stephen Suomi, NICHD). The determination of biomarkers for these syndromes can then be used for colony screening and the development of new prevention strategies. Elucidation of novel biomarkers of SIB will also have significant implications for our understanding of this disorder in human clinical populations.