EFFECTS OF SHAMPOO AND WATER WASHING ON HAIR CORTISOL CONCENTRATIONS

洗发水和水洗对头发皮质醇浓度的影响

• 批准号: 8358018
• 负责人: Melinda Ann Novak
• 金额: $ 5.4万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358018
• 关键词: Biological Markers; Chronic stress; Elements; Exposure to; Funding; Grant; Hair; Hair shaft structure; Housing; Human; Hydrocortisone; In Vitro; Laboratories; Macaca mulatta; Measurement; Monkeys; National Center for Research Resources; Nature; Neck; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Testing; United States National Institutes of Health; Water; base; cost; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Measurement of cortisol in hair is emerging as a biomarker for chronic stress in human and nonhuman primates. Because of its external nature, hair is potentially vulnerable to a loss of cortisol from within the hair shaft due to repeated exposure to various substances such as shampoo (in humans) and water (in free-ranging monkeys). This study examined the influence of both factors on the hair cortisol levels of indoor laboratory housed rhesus monkeys. The effect of shampoo and water cannot be tested in humans because of the need to have hair that had no prior exposure to these elements. Hair was shampooed and exposed to water in vitro (i.e., after it had been gently shaved from the nape of the neck of the rhesus monkeys).

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 毛发中皮质醇的测量正在成为人类和非人类灵长类动物慢性应激的生物标志物。由于其外在的性质，头发可能容易受到皮质醇从毛干内的损失，由于反复暴露于各种物质，如洗发水（人类）和水（自由放养的猴子）。 本研究探讨了这两种因素对室内实验室饲养的恒河猴毛发皮质醇水平的影响。 洗发水和水的效果不能在人类身上测试，因为需要有头发，没有事先暴露于这些元素。 将头发用洗发剂洗涤并在体外暴露于水（即，在从恒河猴的颈背轻轻地剃掉之后）。