ESTABLISHING PREDICTORS OF SIB IN RHESUS MONKEYS

建立恒河猴 SIB 的预测因子

• 批准号: 7958343
• 负责人: Melinda Ann Novak
• 金额: $ 6.49万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958343
• 关键词: Animal Model; Behavior; Behavior assessment; Biological Assay; Biological Markers; Clinical; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Funding; Genetic Variation; Grant; Hair; Housing; Human; Hydrocortisone; Institution; Longitudinal Studies; Macaca; Macaca mulatta; Monkeys; National Institute of Child Health and Human Development; New England; Opioid; Population; Prevention strategy; Primates; Research; Research Personnel; Resources; Risk Factors; Saliva; Sampling; Screening procedure; Source; Syndrome; United States National Institutes of Health; base; biological adaptation to stress; cohort; male; novel; stereotypy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have previously established an animal model of naturally occurring SIB in which monkeys show a reduced stress response and lower opioid levels compared to controls. Because we study monkeys only after they have spontaneously developed SIB, we do not know whether these differences are risk factors for or consequences of developing SIB. The purpose of this project is to determine whether there are early markers for the onset of SIB and stereotypic behavior. We are currently conducting a unique, large-scale longitudinal study of a cohort of male monkeys in which we are coordinating our standard behavioral assessments of abnormal behavior, collecting hair and saliva samples for cortisol and other assays, and searching for polymorphic gene variants that are predictive of later SIB or stereotypy development. We are also examining hair cortisol profiles in macaques as a function of housing, early rearing, and species (in collaboration with Dr. Stephen Suomi, NICHD). The determination of biomarkers for these syndromes can then be used for colony screening and the development of new prevention strategies. Elucidation of novel biomarkers of SIB will also have significant implications for our understanding of this disorder in human clinical populations.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们以前已经建立了一种天然发生的SIB动物模型，与对照组相比，猴子表现出降低的应力反应和降低的阿片类药物水平。 因为我们只有在自发发展SIB后才研究它们，所以我们不知道这些差异是发展SIB的风险因素还是后果。 该项目的目的是确定SIB和刻板印象的发作是否有早期标记。 目前，我们正在对一系列雄性猴子进行独特的大规模纵向研究，其中我们正在协调对异常行为的标准行为评估，收集头发和唾液样品，用于皮质醇和其他测定法，并搜索多型基因变种，以预测后来的SIB SIB或STEREREPY型开发。 我们还正在检查猕猴中的皮质蛋白酶剖面，这是住房，早期饲养和物种的函数（与NICHD的Stephen Suomi博士合作）。 然后，可以将这些综合征生物标志物的确定用于菌落筛查和新预防策略的发展。 阐明新型SIB的生物标志物也将对我们在人类临床人群中对这种疾病的理解产生重大影响。