EFFECTS OF THE ENVIRONMENT ON HAIR CORTISOL LEVELS IN MACAQUES AND MAMMALS

环境对猕猴和哺乳动物毛发皮质醇水平的影响

• 批准号: 8358017
• 负责人: Melinda Ann Novak
• 金额: $ 5.4万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358017
• 关键词: Biological Markers; Chronic stress; Earthquakes; Employment Status; Environment; Funding; Grant; Hair; Human; Hydrocortisone; Macaca; Macaca mulatta; Mammals; Measurement; National Center for Research Resources; Natural Disasters; New England; Polar Bear; Pregnancy; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; base; chronic pain; cost; human subject; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Measurement of cortisol in hair is emerging as a biomarker for chronic stress in human and nonhuman primates. For example, we recently found that rhesus monkeys subjected to a mandatory relocation had increased hair cortisol following the move. In human subjects, hair cortisol levels have been shown to be sensitive to employment status, chronic pain, pregnancy, and natural disasters such as earthquakes. In this project, we continue our exploration of environmental effects on a variety of species including primates and polar bears.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 毛发中皮质醇的测量正在成为人类和非人类灵长类动物慢性应激的生物标志物。例如，我们最近发现，被强制搬迁的恒河猴在搬迁后毛发皮质醇增加。 在人类受试者中，头发皮质醇水平已被证明对就业状况，慢性疼痛，怀孕和地震等自然灾害敏感。 在这个项目中，我们继续探索环境对各种物种的影响，包括灵长类动物和北极熊。