ACCOMMODATING INTRAOCULAR LENSES

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 目的：观察人工晶状体植入恒河猴后对中枢神经系统刺激的恢复能力。 将电极植入6只恒河猴的Edinger-Westphal核，使调节能被中枢刺激。 透镜物质被Nu透镜公司设计的人工晶状体所取代。 使用屈光测定法和超声生物显微镜测定这些晶状体在中枢刺激后调节、改变形状和位置的能力。 在刺激期间诱导8.0屈光度的调节。 因此，这些镜片有可能逆转随着年龄增长而出现的老花眼。经确定，4只因眼内透镜手术和严重角膜混浊而出现炎症的动物需要在一只或两只眼睛中进行角膜移植。找到供体猴并进行角膜移植。移植后4个月，裂隙灯检查（SLE）显示两只动物无排斥反应迹象，但所有角膜均出现轻微模糊。在双侧给药的猴中，模糊更为明显。Neal Barney博士是我们的角膜专家之一，自移植手术以来，他对这些动物进行了多次检查。他认为这些动物将保持略微模糊的角膜，但成功地耐受了移植手术，其外观和行为与改善的视力一致。 由于在角膜混浊更明显的两只动物中未收集到可测量的调节数据，因此对这些动物实施安乐死。 三只恒河猴在IOL植入后至少8个月保持3至8屈光度的调节。每季度进行一次实验，以记录NuLens IOL的功能。另外2只恒河猴可能将接受电极植入，然后植入下一代NuLens IOL。 这项研究使用WNPRC研究服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the accommodative ability of intraocular lenses in rhesus monkeys following central stimulation. Electrodes were implanted into the Edinger Westphal nucleus of 6 rhesus monkeys so that accommodation could be stimulated centrally. The lens substance was replaced with artificial lenses designed by NuLens. The ability of these lenses to accommodate, change shape and position after central stimulation was determined using refractometry and ultrasound biomicroscopy. Accommodation of 8.0 diopters was induced during stimulation. Thus, these lenses have the potential to reverse the onset of presbyopia with age. It was determined that four animals with inflammation due to the intraocular lens surgery and severe corneal opacification required a corneal transplant in one or both eyes. Donor monkeys were located and corneal transplants were performed. Four months post transplant, slit lamp examination (SLE) revealed no rejection signs in two animals, but all corneas appeared slightly hazy. The haziness was more pronounced in the bilaterally treated monkeys. Dr. Neal Barney, one of our corneal specialists, examined these animals numerous times since their transplant procedure. He felt that these animals would maintain slightly hazy corneas, but had successfully tolerated the transplant procedure with an appearance and behavior consistent with improved vision. Since no measurable accommodation data was gathered in the two animals with more pronounced cornea haziness, those animals were euthanized. Three rhesus monkeys maintain accommodation from 3 to 8 diopters for at least eight months post IOL insertion. Experiments are conducted quarterly to document the NuLens IOL functionality. Potentially two additional rhesus monkeys will receive an electrode implant followed by the next generation NuLens IOL. This research used WNPRC Research Services.