ACCOMMODATING INTRAOCULAR LENSES

调节人工晶状体

• 批准号: 8173099
• 负责人: PAUL L KAUFMAN
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173099
• 关键词: Age; Animals; Appearance; Behavior; Cell Nucleus; Computer Retrieval of Information on Scientific Projects Database; Cornea; Data; Electrodes; Eye; Funding; Grant; Implant; Implanted Electrodes; Inflammation; Institution; Intraocular lens implant device; Keratoplasty; Macaca mulatta; Measurable; Monkeys; Operative Surgical Procedures; Positioning Attribute; Presbyopia; Procedures; Refractometry; Research; Research Personnel; Resources; Services; Shapes; Source; Specialist; Time; Transplantation; Ultrasonographic Biomicroscopy; United States National Institutes of Health; Vision; design; device Artificial lens; improved; lens; next generation; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the accommodative ability of intraocular lenses in rhesus monkeys following central stimulation. Electrodes were implanted into the Edinger Westphal nucleus of 6 rhesus monkeys so that accommodation could be stimulated centrally. The lens substance was replaced with artificial lenses designed by NuLens. The ability of these lenses to accommodate, change shape and position after central stimulation was determined using refractometry and ultrasound biomicroscopy. Accommodation of 8.0 diopters was induced during stimulation. Thus, these lenses have the potential to reverse the onset of presbyopia with age. It was determined that four animals with inflammation due to the intraocular lens surgery and severe corneal opacification required a corneal transplant in one or both eyes. Donor monkeys were located and corneal transplants were performed. Four months post transplant, slit lamp examination (SLE) revealed no rejection signs in two animals, but all corneas appeared slightly hazy. The haziness was more pronounced in the bilaterally treated monkeys. Dr. Neal Barney, one of our corneal specialists, examined these animals numerous times since their transplant procedure. He felt that these animals would maintain slightly hazy corneas, but had successfully tolerated the transplant procedure with an appearance and behavior consistent with improved vision. Since no measurable accommodation data was gathered in the two animals with more pronounced cornea haziness, those animals were euthanized. Three rhesus monkeys maintain accommodation from 3 to 8 diopters for at least eight months post IOL insertion. Experiments are conducted quarterly to document the NuLens IOL functionality. Potentially two additional rhesus monkeys will receive an electrode implant followed by the next generation NuLens IOL. This research used WNPRC Research Services.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：确定恒河猴中枢刺激后人工晶状体的调节能力。 将电极植入 6 只恒河猴的 Edinger Westphal 核中，以便集中刺激调节。 镜片物质被 NuLens 设计的人造镜片取代。 使用折射测量和超声生物显微镜确定这些晶状体在中枢刺激后适应、改变形状和位置的能力。 在刺激期间诱导8.0屈光度的调节。 因此，这些镜片有可能逆转随着年龄增长而出现的老花眼。经确定，四只因人工晶状体手术引起炎症和严重角膜混浊的动物需要一只或两只眼睛进行角膜移植。找到供体猴并进行角膜移植。移植后四个月，裂隙灯检查（SLE）显示两只动物没有排斥迹象，但所有角膜都显得有些模糊。在双侧治疗的猴子中，这种模糊现象更为明显。我们的一位角膜专家尼尔·巴尼博士自移植手术以来对这些动物进行了多次检查。他认为这些动物将保持轻微模糊的角膜，但已成功耐受移植手术，其外观和行为与视力改善一致。 由于在角膜混浊更明显的两只动物中没有收集到可测量的调节数据，因此对这些动物实施安乐死。 三只恒河猴在人工晶状体植入后至少八个月内保持 3 至 8 屈光度的调节。每季度进行一次实验来记录 NuLens IOL 功能。可能会有另外两只恒河猴接受电极植入，然后接受下一代 NuLens IOL。 本研究使用了 WNPRC 研究服务。