ACCOMMODATING INTRAOCULAR LENSES

调节人工晶状体

• 批准号: 8358209
• 负责人: PAUL L KAUFMAN
• 金额: $ 0.78万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358209
• 关键词: Age; Animals; Cell Nucleus; Cornea; Data; Electrodes; Eye; Funding; Grant; Implant; Implanted Electrodes; Inflammation; Intraocular lens implant device; Keratoplasty; Macaca mulatta; Monkeys; National Center for Research Resources; Operative Surgical Procedures; Pathology; Positioning Attribute; Presbyopia; Primates; Principal Investigator; Refractometry; Research; Research Infrastructure; Resources; Services; Shapes; Source; Ultrasonographic Biomicroscopy; United States National Institutes of Health; Wisconsin; cost; design; device Artificial lens; lens; next generation; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To determine the accommodative ability of intraocular lenses in rhesus monkeys following central stimulation. PROGRESS: Electrodes were implanted into the Edinger Westphal nucleus of 6 rhesus monkeys so that accommodation could be stimulated centrally. The lens substance was replaced with artificial lenses designed by NuLens. The ability of these lenses to accommodate, change shape and position after central stimulation was determined using refractometry and ultrasound biomicroscopy. Accommodation of 8.0 diopters was induced during stimulation. Thus, these lenses have the potential to reverse the onset of presbyopia with age. It was determined that four animals with inflammation due to the intraocular lens surgery and severe corneal opacification required a corneal transplant in one or both eyes. Donor monkeys were located and corneal transplants were performed. Accommodation experiments were conducted. Once accommodation data could no longer be gathered, all four animals were euthanized. Two rhesus monkeys each maintain accommodation from 3 to 8 diopters in one eye. Experiments are conducted quarterly to document NuLens IOL functionality. Potentially two additional rhesus monkeys will receive an electrode implant followed by the next generation NuLens IOL. This research used WNPRC Animal and Pathology Services. PUBLICATIONS: None.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 目的：确定中央刺激后恒河猴中眼内镜头的可容纳能力。 进步： 将电极植入了6只恒河猴的Edinger Westphal核中，以便可以在中心刺激适应。 将镜头物质代替由努龙设计的人造镜头。 使用折射率和超声生物显微镜确定这些镜头可容纳，改变形状和位置的能力。在刺激期间诱导了8.0局的容纳。 因此，这些镜片有可能随着年龄的增长而扭转长老会的发作。据确定，由于眼内晶状体手术和严重的角膜无情而引起炎症的四只动物需要一只或两只眼睛的角膜移植。位置并进行了角膜移植。进行了住宿实验。一旦无法收集住宿数据，所有四只动物就被安乐死了。 一只眼睛，两只恒河猴每眼都从3到8个屈光者维持住宿。实验是每季度进行的，以记录Nulens IOL功能。 潜在的另外两个恒河猴将接收一个电极植入物，然后再获得下一代Nulens IOL。 这项研究使用了WNPRC动物和病理服务。 出版物： 没有任何。