ACCOMMODATING INTRAOCULAR LENSES

调节人工晶状体

• 批准号: 8358209
• 负责人: PAUL L KAUFMAN
• 金额: $ 0.78万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358209
• 关键词: Age; Animals; Cell Nucleus; Cornea; Data; Electrodes; Eye; Funding; Grant; Implant; Implanted Electrodes; Inflammation; Intraocular lens implant device; Keratoplasty; Macaca mulatta; Monkeys; National Center for Research Resources; Operative Surgical Procedures; Pathology; Positioning Attribute; Presbyopia; Primates; Principal Investigator; Refractometry; Research; Research Infrastructure; Resources; Services; Shapes; Source; Ultrasonographic Biomicroscopy; United States National Institutes of Health; Wisconsin; cost; design; device Artificial lens; lens; next generation; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To determine the accommodative ability of intraocular lenses in rhesus monkeys following central stimulation. PROGRESS: Electrodes were implanted into the Edinger Westphal nucleus of 6 rhesus monkeys so that accommodation could be stimulated centrally. The lens substance was replaced with artificial lenses designed by NuLens. The ability of these lenses to accommodate, change shape and position after central stimulation was determined using refractometry and ultrasound biomicroscopy. Accommodation of 8.0 diopters was induced during stimulation. Thus, these lenses have the potential to reverse the onset of presbyopia with age. It was determined that four animals with inflammation due to the intraocular lens surgery and severe corneal opacification required a corneal transplant in one or both eyes. Donor monkeys were located and corneal transplants were performed. Accommodation experiments were conducted. Once accommodation data could no longer be gathered, all four animals were euthanized. Two rhesus monkeys each maintain accommodation from 3 to 8 diopters in one eye. Experiments are conducted quarterly to document NuLens IOL functionality. Potentially two additional rhesus monkeys will receive an electrode implant followed by the next generation NuLens IOL. This research used WNPRC Animal and Pathology Services. PUBLICATIONS: None.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 目的：观察人工晶状体植入恒河猴后对中枢神经系统刺激的恢复能力。 进展： 将电极植入6只恒河猴的Edinger Westphal核，使调节能被中枢刺激。 透镜物质被Nu透镜公司设计的人工晶状体所取代。 使用屈光测定法和超声生物显微镜测定这些晶状体在中枢刺激后调节、改变形状和位置的能力。在刺激期间诱导8.0屈光度的调节。 因此，这些镜片有可能逆转随着年龄增长而出现的老花眼。经确定，4只因眼内透镜手术和严重角膜混浊而出现炎症的动物需要在一只或两只眼睛中进行角膜移植。找到供体猴并进行角膜移植。进行了适应性实验。一旦无法再收集适应数据，则对所有4只动物实施安乐死。 两只恒河猴各保持一只眼睛的3至8屈光度的调节。每季度进行一次实验，以记录NuLens IOL的功能。 另外2只恒河猴可能将接受电极植入，然后植入下一代NuLens IOL。 本研究使用WNPRC动物和病理学服务。 出版物： 没有。