ACCOMMODATING INTRAOCULAR LENSES

调节人工晶状体

• 批准号: 8358209
• 负责人: PAUL L KAUFMAN
• 金额: $ 0.78万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358209
• 关键词: Age; Animals; Cell Nucleus; Cornea; Data; Electrodes; Eye; Funding; Grant; Implant; Implanted Electrodes; Inflammation; Intraocular lens implant device; Keratoplasty; Macaca mulatta; Monkeys; National Center for Research Resources; Operative Surgical Procedures; Pathology; Positioning Attribute; Presbyopia; Primates; Principal Investigator; Refractometry; Research; Research Infrastructure; Resources; Services; Shapes; Source; Ultrasonographic Biomicroscopy; United States National Institutes of Health; Wisconsin; cost; design; device Artificial lens; lens; next generation; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To determine the accommodative ability of intraocular lenses in rhesus monkeys following central stimulation. PROGRESS: Electrodes were implanted into the Edinger Westphal nucleus of 6 rhesus monkeys so that accommodation could be stimulated centrally. The lens substance was replaced with artificial lenses designed by NuLens. The ability of these lenses to accommodate, change shape and position after central stimulation was determined using refractometry and ultrasound biomicroscopy. Accommodation of 8.0 diopters was induced during stimulation. Thus, these lenses have the potential to reverse the onset of presbyopia with age. It was determined that four animals with inflammation due to the intraocular lens surgery and severe corneal opacification required a corneal transplant in one or both eyes. Donor monkeys were located and corneal transplants were performed. Accommodation experiments were conducted. Once accommodation data could no longer be gathered, all four animals were euthanized. Two rhesus monkeys each maintain accommodation from 3 to 8 diopters in one eye. Experiments are conducted quarterly to document NuLens IOL functionality. Potentially two additional rhesus monkeys will receive an electrode implant followed by the next generation NuLens IOL. This research used WNPRC Animal and Pathology Services. PUBLICATIONS: None.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：研究中枢刺激对恒河猴人工晶状体调节能力的影响。 进度： 将电极植入6只恒河猴的Edinger Westphal核内，以实现中枢调节。镜片物质被NuLens设计的人造镜片取代。用折射法和超声生物显微镜测定这些晶状体在中枢刺激后适应、改变形状和位置的能力。刺激诱导调节度数为8.0度。因此，这些镜片有可能逆转随着年龄增长的老花眼的发病。已确定四只因人工晶状体手术和严重的角膜混浊而发炎的动物需要在一只眼或双眼接受角膜移植。对供体猴进行定位，并进行角膜移植。进行了住宿实验。一旦无法再收集住宿数据，所有四只动物都被安乐死。 两只恒河猴各有一只眼的屈光度在3到8度之间。每季度进行一次实验，以记录NuLens IOL的功能。可能会有另外两只恒河猴接受电极植入，随后是下一代NuLens IOL。 这项研究使用了WNPRC动物和病理服务中心。 出版物： 没有。