CILIARY MUSCLE AGING AND PRESBYOPIA

睫状肌老化和老花眼

• 批准号: 8173059
• 负责人: PAUL L KAUFMAN
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173059
• 关键词: Affect; Age; Aging; Biological; Caliber; Ciliary Body; Ciliary Muscle; Computer Retrieval of Information on Scientific Projects Database; Eye; Funding; Grant; Human; Institution; Macaca mulatta; Modeling; Monkeys; Morphology; Movement; Muscle; Presbyopia; Printing; Relative (related person); Research; Research Personnel; Resources; Services; Shapes; Source; Structure; United States National Institutes of Health; Width; age related; design; insight; lens; muscle aging; nonhuman primate; vector

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To understand human presbyopia by studying the dynamics of accommodation and presbyopia in nonhuman primates. Nonhuman primates are the preferred model for human presbyopia, the age-related loss of the ability to focus. Focus depends on the ability of the lens to change shape (i.e. lens thickening and a concomitant decrease in lens equatorial diameter). Lens shape change depends upon forward and inward movement of the ciliary muscle. Previously, we found an age-related in loss in ciliary muscle movement that was more pronounced in the forward rather than the centripetal vector. Current findings show that accommodative lens thickening declined with age more markedly than accommodative lens diameter. This could be due to simple geometric / biophysical necessity and/or aging changes inherent in lens structure. Age-related changes in accommodative lens thickening may not be the same quantitatively or mechanistically as the age-related changes in accommodative diameter, regardless of the ciliary body state of contraction. The ciliary muscle's ability to maintain some centripetal movement while undergoing a dramatic loss in forward movement with increasing age may also have an impact on differential lens shape changes (i.e., accommodative thickening vs. equatorial movements). Whether the age-related differences in lens thickening vs. lens equator movements are due to the lens itself or to changes in ciliary body movements, these findings may provide insights into successful accommodating IOL design. The presence of the vitreous zonule was confirmed in the human eye. Disruption of the vitreous zonule restored forward muscle movement in the older rhesus monkey eye. This raises the possibility that the vitreous zonule could be a biological target, the disruption of which could be used to restore forward muscle movement. Further, there was an age-related decrease in width of the ciliary body in the vitreous zonule/pars plana region and this may have an effect on the vitreous zonule tension and may affect lens shape and thereby accommodation. Again, these findings may provide some insight into successful accommodating IOL design. This research used WNPRC Research Services. PUBLICATIONS: Croft MA, McDonald JP, Nadkarni NV, Lin TL, Kaufman PL: Age-related changes in centripetal ciliary body movement relative to centripetal lens movement in monkeys. Exp Eye Res 89:824-832, 2009 (Dec) PMCID278077 L¿tjen-Drecoll E, Kaufman PL, Wasielewski R, Lin TL, Croft MA: Morphology and accommodative function of the vitreous zonule in human and monkey eyes. Invest Ophthalmol Vis Sci, Epub ahead of print, Oct 8, 2009.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：通过研究非人类灵长类动物的调节和老花眼的动态来了解人类老花眼。 非人类灵长类动物是人类老花眼（与年龄相关的聚焦能力丧失）的首选模型。焦点取决于晶状体改变形状的能力（即晶状体增厚和晶状体赤道直径随之减小）。晶状体形状的变化取决于睫状肌的向前和向内运动。此前，我们发现与年龄相关的睫状肌运动损失在向前方向而不是向心矢量中更为明显。目前的研究结果表明，随着年龄的增长，调节晶状体厚度的下降比调节晶状体直径的下降更为明显。这可能是由于简单的几何/生物物理必要性和/或晶状体结构固有的老化变化。无论睫状体的收缩状态如何，与年龄相关的可调节晶状体增厚的变化在数量或机制上可能与与年龄相关的可调节直径的变化不同。 随着年龄的增长，睫状肌保持一定向心运动的能力，同时向前运动急剧丧失，这也可能对不同的晶状体形状变化（即调节增厚与赤道运动）产生影响。无论晶状体增厚与晶状体赤道运动的年龄相关差异是由于晶状体本身还是由于睫状体运动的变化，这些发现可能为成功的可调节人工晶状体设计提供见解。 在人眼中证实了玻璃体小带的存在。玻璃体小带的破坏恢复了老年恒河猴眼睛的向前肌肉运动。这提出了玻璃体小带可能是生物目标的可能性，其破坏可用于恢复向前的肌肉运动。此外，玻璃体小带/平坦部区域中的睫状体宽度与年龄相关地减小，这可能对玻璃体小带张力产生影响，并且可能影响晶状体形状，从而影响调节。同样，这些发现可能为成功调节人工晶状体设计提供一些见解。 本研究使用了 WNPRC 研究服务。 出版物： Croft MA、McDonald JP、Nadkarni NV、Lin TL、Kaufman PL：猴子向心睫状体运动相对于向心晶状体运动的年龄相关变化。实验眼研究 89:824-832，2009 年（12 月）PMCID278077 L¿tjen-Drecoll E、Kaufman PL、Wasielewski R、Lin TL、Croft MA：人和猴眼玻璃体小带的形态学和调节功能。 Invest Ophamol Vis Sci，印刷前电子版，2009 年 10 月 8 日。