LENS LASER STRATEGIES FOR PRESBYOPIA

老花眼的晶状体激光治疗策略

• 批准号: 8358210
• 负责人: PAUL L KAUFMAN
• 金额: $ 0.78万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358210
• 关键词: Animals; Behavior; Burn injury; Cell Nucleus; Electrodes; Exhibits; Eye; Funding; Future; Grant; Hour; Housing; Implant; Lasers; Macaca mulatta; Measurement; Monitor; Monkeys; National Center for Research Resources; Pain; Pathology; Presbyopia; Primates; Principal Investigator; Procedures; Research; Research Infrastructure; Resources; Retinal; Services; Source; Testing; United States National Institutes of Health; Vision; Wisconsin; cost; lens; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To determine the accommodative ability in older rhesus monkeys following central stimulation before and after lens lasering. RESULTS: Currently, monkeys that received laser treatment of the lens are being housed for long-term observations. Previously, an electrode was implanted into the Edinger- Westphal nucleus of each of 2 older rhesus monkeys so that accommodation could be stimulated centrally. In addition, 4 young rhesus monkeys were used as test subjects to calibrate the femtosecond laser. Baseline testing was completed prior to determination of the effects of lens lasering on the accommodative response. The femtosecond laser procedure appears to be well tolerated in the monkey eye. However, small retinal burns (1-2 mm in size) were noted in 2 out of 5 monkeys lasered. The ability to obtain refractive measurements with the Hartinger coincidence refractometer was not compromised by the femtosecond laser procedure beginning 24 hours after lasering. Animals did not exhibit abnormal behavior or evidence of pain or discomfort. Slit lamp examinations are performed bi-annually in the remaining four rhesus monkeys. All animals maintain normal vision. Presently the animals continue to be monitored and future experimental plans are being considered. This research used WNPRC Animal and Pathology Services.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 目的：确定晶状体激光前后的中央刺激后，较老的恒河猴的适应能力。 结果： 目前，接受了对镜头的激光治疗的猴子正在容纳长期观察。 以前，将电极植入了2个较老的恒河猴中的每个核的Edinger-Westphal核中，以便可以将其集中刺激。此外，将4个年轻的恒河猴用作测试对象，以校准飞秒激光。 在确定晶状体激光对适应性响应的影响之前完成了基线测试。飞秒激光程序似乎在猴子眼中耐受性良好。然而，在5个猴子中的2个猴子中，有2只视网膜燃烧（1-2毫米）。从激光后24小时开始，飞秒激光程序并未损害与Hartinger重合折射仪获得折射测量的能力。动物没有表现出异常的行为或疼痛或不适的证据。 在其余四个恒河猴中双年度进行缝隙灯检查。所有动物都保持正常视力。目前，仍在监视这些动物，并正在考虑未来的实验计划。 这项研究使用了WNPRC动物和病理服务。