LENS LASER STRATEGIES FOR PRESBYOPIA

老花眼的晶状体激光治疗策略

• 批准号: 8358210
• 负责人: PAUL L KAUFMAN
• 金额: $ 0.78万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358210
• 关键词: Animals; Behavior; Burn injury; Cell Nucleus; Electrodes; Exhibits; Eye; Funding; Future; Grant; Hour; Housing; Implant; Lasers; Macaca mulatta; Measurement; Monitor; Monkeys; National Center for Research Resources; Pain; Pathology; Presbyopia; Primates; Principal Investigator; Procedures; Research; Research Infrastructure; Resources; Retinal; Services; Source; Testing; United States National Institutes of Health; Vision; Wisconsin; cost; lens; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To determine the accommodative ability in older rhesus monkeys following central stimulation before and after lens lasering. RESULTS: Currently, monkeys that received laser treatment of the lens are being housed for long-term observations. Previously, an electrode was implanted into the Edinger- Westphal nucleus of each of 2 older rhesus monkeys so that accommodation could be stimulated centrally. In addition, 4 young rhesus monkeys were used as test subjects to calibrate the femtosecond laser. Baseline testing was completed prior to determination of the effects of lens lasering on the accommodative response. The femtosecond laser procedure appears to be well tolerated in the monkey eye. However, small retinal burns (1-2 mm in size) were noted in 2 out of 5 monkeys lasered. The ability to obtain refractive measurements with the Hartinger coincidence refractometer was not compromised by the femtosecond laser procedure beginning 24 hours after lasering. Animals did not exhibit abnormal behavior or evidence of pain or discomfort. Slit lamp examinations are performed bi-annually in the remaining four rhesus monkeys. All animals maintain normal vision. Presently the animals continue to be monitored and future experimental plans are being considered. This research used WNPRC Animal and Pathology Services.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：测定老年恒河猴晶状体激光治疗前后中枢刺激后的调节能力。 结果： 目前，接受晶状体激光治疗的猴子正被安置在笼子里进行长期观察。此前，在2只年长恒河猴的Edinger-Westphal核中各植入一个电极，这样就可以在中枢刺激调节。此外，还以4只幼龄恒河猴为实验对象，对飞秒激光进行了定标。基线测试是在确定晶状体激光对调节反应的影响之前完成的。这种飞秒激光手术似乎对猴眼有很好的耐受性。然而，在接受激光治疗的5只猴子中，有2只观察到视网膜小面积烧伤(1-2 mm)。使用哈廷格符合验光仪获得屈光测量的能力不受飞秒激光程序的影响，飞秒激光程序在激光24小时后开始。动物没有表现出异常行为或疼痛或不适的证据。 其余四只恒河猴每两年进行一次裂隙灯检查。所有的动物都保持正常的视力。目前，这些动物仍在接受监测，未来的实验计划也在考虑之中。 这项研究使用了WNPRC动物和病理服务中心。