INDUCED PLURIPOTENT STEM CELL (IPSC) THERAPY FOR BLOOD DISORDERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：建立诱导多能干细胞(IPSC)治疗血液病的恒河猴模型。 作为与汤姆森博士合作的一部分，我们正在使用从成年恒河猴建立的非人类灵长类iPSCs来生成血细胞，包括红细胞、树突状细胞和造血干细胞。随后，这些细胞将在恒河猴身上进行测试，以证明这种方法治疗人类疾病的可行性。 这项研究使用了WNPRC干细胞资源和启动资金。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To establish a rhesus monkey model for induced pluripotent stem cells (iPSC)-therapy of blood disorders. As a part of collaboration with Dr. Thomson, we are using non-human primate-iPSCs established from adult rhesus monkeys for generation of blood cells including red blood cells, dendritic cells, and hematopoietic stem cells. Subsequently these cells will be tested in rhesus monkeys to demonstrate feasibility of such approach for treatment of human diseases. This research used WNPRC Stem Cell Resources and start-up funding.