NEUROLOGICAL DEFICIT AS A RESULT OF TENSION-EXTENSION OF THE CERVICAL SPINE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在成功实现神经组织再生之前，预防脊髓损伤(SCI)是减轻其后遗症的首要任务。目前，超过25万名美国脊髓损伤患者必须忍受其令人衰弱的后果，通过现有的治疗几乎没有改善的希望。虽然对神经再生和修复的有希望的研究工作正在进行中，但损伤预防提供了一种避免脊髓损伤的方法，这种方法总是比治疗更可取。 预防脊髓损伤的关键之一是了解人类对作用于脊柱的潜在伤害力的耐受限度(即暴露限度)。预防策略和设备依赖于这些知识，以便开发有效的设计并对其性能进行台架测试。以前的损伤研究提供了基于脊柱结构性故障的暴露限值，但这些限值并没有提供神经组织是否受到损害的指示。因为脊髓损伤的发生可能没有脊柱的结构性损伤，所以这项研究试图调查神经损伤的阈值(开始)，以帮助确定更保守的暴露限制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Until the regeneration of neural tissues is successfully achieved, the prevention of spinal cord injury (SCI) is paramount in mitigating its sequelae. Currently, over 250,000 Americans with SCI must endure its debilitating consequences with little hope of improvement through existing medical treatment. While promising research efforts toward neuro-regeneration and repair are underway, injury prevention offers a means of avoiding SCI which will always be preferable to treatment. One of the keys to preventing SCI is in understanding the limits of human tolerance (i.e., exposure limits) to potential injurious forces acting on the spine. Prevention strategies and devices depend on this knowledge in order to develop effective designs and bench test their performance. Previous injury research has provided exposure limits based on structural failure of the spinal column, but these limits do not provide an indication of the whether the neurologic tissues have been damaged. Because SCI may occur without structural failure of the spine, this study seeks to investigate the threshold (onset) of neurological injury to help determine more conservative exposure limits.