First Symposium on Head and Neck Cancer Stem Cells

第一届头颈癌干细胞研讨会

• 批准号: 8198917
• 负责人: Jacques Eduardo Nor
• 金额: $ 2万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8198917
• 关键词: Acceleration; Area; Attention; Award; Cells; Collaborations; Colorectal; Communities; Conceptions; Dental; Development; Disabled Persons; Discipline; Disease; Ensure; Equilibrium; Fostering; Generations; Goals; Grant; Head and Neck Cancer; Head and Neck Neoplasms; Head and neck structure; Industry; Knowledge; Laboratory Finding; Lead; Malignant Neoplasms; Medical; Michigan; Minority; Oncologist; Oral; Otolaryngologist; Outcome; Participant; Pathologist; Patient Care; Patients; Play; Process; Public Health; Publishing; Quality of life; Research; Research Methodology; Research Personnel; Research Project Grants; Role; Science; Scientist; Speed; Stem Cell Research; Stem cells; Surgeon; Therapeutic; Time; Translations; Travel; Universities; Woman; Work; abstracting; base; cancer stem cell; cancer type; carcinogenesis; clinical application; clinical practice; design; expectation; experience; head and neck cancer patient; improved; interest; malignant breast neoplasm; maxillofacial; meetings; melanoma; next generation; oncology; stem cell biology; stem cell population; symposium; tumor; tumor growth; tumor progression; tumorigenic

DESCRIPTION (provided by applicant): The First Symposium on Head and Neck Cancer Stem Cells is planned for May 10-11, 2012, at the campus of the University of Michigan in Ann Arbor. Stem cells play an important role in the pathobiology of cancer. However, the impact of stem cells in the initiation and progression of cancer is tumor-type specific. While in certain tumors most cells are highly tumorigenic (e.g. melanoma), in others there is a small sub-population of stem cells that are the primary responsible for the initiation and progression of the tumor (e.g. breast cancer). This Symposium will be the first one to focus on the role of stem cells in head and neck carcinogenesis. The understanding of the biology of stem cells in head and neck cancer is pivotal for the development of new strategies to identify these cells and to selectively eliminate their contribution to tumor growth and progression. The overall goal of this Symposium is to present and discuss the most recent advances in the area of cancer stem cell biology, stimulate state-of-the-art collaborative new research projects in this field, and use the new knowledge in the design of more efficacious and safer therapies for head and neck cancer patients. The specific aims of this Symposium are A) To present and discuss the state-of-the-science in cancer stem cell biology; B) To present and discuss the role of stem cells in the pathobiology of head and neck cancer; C) To identify challenges that impedes progress in head and neck cancer stem cell research and propose strategies to overcome these roadblocks; D) To foster lively scientific exchanges among leading scientists and young researchers engaged in cancer stem cell research; and E) To disseminate the symposium presentations by publishing its proceedings. We have worked extensively to attract outstanding scientists across a spectrum of disciplines for this Symposium. We expect that the audience will likely include dental and medical scientists, pathologists, oncologists, otolaryngologists, oral maxillofacial surgeons, biologists, and mathematicians with a common interest in stem cells and head and neck cancer. We anticipate 80-120 participants. The Symposium is organized in 4 main sessions over a period of 2 days, with 1 keynote talk, followed by 3 research talks, and ample time for discussion in each session. To cultivate the next generation of scientists, young investigators will be encouraged to attend by granting 12 travel awards distributed in a competitive basis, as well as by selecting up to 8 Abstracts from young investigators for short oral presentations. The organizing committee will provide careful consideration in selecting speakers and participants to foster a balanced audience and to ensure ample opportunities for participation of women, minorities, and persons with disabilities. The expected outcomes of this Symposium include the dissemination of the knowledge in this emerging area of head and neck oncology, the establishment of new research collaborations, and the acceleration of the translation of laboratory findings into improved therapies for patients suffering from head and neck cancer. PUBLIC HEALTH RELEVANCE: The relevance to public health of the proposed First Symposium on Head and Neck Cancer Stem Cells lies in its potential to accelerate the process of discovery of safer and more efficacious therapies for patients with advanced head and neck cancer. This is critical since the current benefits of therapy are modest for these patients, and their 5-year survival remains very low. The overall goal of this Symposium is to disseminate the most recent advances in the area of cancer stem cell biology and stimulate collaborative new research projects in this field, with the ultimate goal of developing new therapies that aim at improving the survival and quality of life of patients suffering from head and neck cancer.

描述（由申请人提供）：第一届头颈癌干细胞研讨会计划于 2012 年 5 月 10 日至 11 日在安娜堡密歇根大学校园举行。干细胞在癌症病理学中发挥着重要作用。然而，干细胞对癌症发生和进展的影响具有肿瘤类型特异性。虽然在某些肿瘤中，大多数细胞具有高度致瘤性（例如黑色素瘤），但在其他肿瘤中，有一小部分干细胞是肿瘤（例如乳腺癌）发生和进展的主要负责人。本次研讨会将是第一个重点关注干细胞在头颈癌发生中的作用的研讨会。了解头颈癌干细胞的生物学特性对于开发识别这些细胞并选择性消除它们对肿瘤生长和进展的贡献的新策略至关重要。本次研讨会的总体目标是介绍和讨论癌症干细胞生物学领域的最新进展，激发该领域最先进的合作新研究项目，并利用新知识为头颈癌患者设计更有效、更安全的疗法。本次研讨会的具体目标是 A) 展示和讨论癌症干细胞生物学的最新科学进展； B) 介绍并讨论干细胞在头颈癌病理学中的作用； C) 找出阻碍头颈癌干细胞研究进展的挑战，并提出克服这些障碍的策略； D) 促进从事癌症干细胞研究的顶尖科学家和年轻研究人员之间活跃的科学交流； E) 通过出版会议记录来传播研讨会报告。我们进行了广泛的努力，吸引了各学科的杰出科学家参加本次研讨会。我们预计观众可能包括对干细胞和头颈癌有共同兴趣的牙科和医学科学家、病理学家、肿瘤学家、耳鼻喉科医生、口腔颌面外科医生、生物学家和数学家。我们预计有 80-120 名参与者。会议为期两天，分为4个主要会议，其中1场主题演讲，随后3场研究报告，每场会议都有充足的讨论时间。为了培养下一代科学家，将鼓励年轻研究者参加，以竞争方式颁发 12 个旅行奖，并选择最多 8 篇来自年轻研究者的摘要进行简短的口头报告。组委会将仔细考虑选择演讲者和参与者，以培养均衡的受众，并确保妇女、少数族裔和残疾人有充足的参与机会。本次研讨会的预期成果包括传播头颈肿瘤学这一新兴领域的知识、建立新的研究合作以及加速将实验室研究结果转化为针对头颈癌患者的改进疗法。 公共健康相关性：拟议的第一届头颈癌干细胞研讨会与公共健康的相关性在于它有可能加速为晚期头颈癌患者发现更安全、更有效的疗法的过程。这一点至关重要，因为目前治疗对这些患者的益处不大，而且他们的 5 年生存率仍然很低。本次研讨会的总体目标是传播癌症干细胞生物学领域的最新进展，并促进该领域的合作新研究项目，最终目标是开发旨在改善头颈癌患者生存和生活质量的新疗法。