First Symposium on Head and Neck Cancer Stem Cells

第一届头颈癌干细胞研讨会

• 批准号: 8198917
• 负责人: Jacques Eduardo Nor
• 金额: $ 2万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8198917
• 关键词: Acceleration; Area; Attention; Award; Cells; Collaborations; Colorectal; Communities; Conceptions; Dental; Development; Disabled Persons; Discipline; Disease; Ensure; Equilibrium; Fostering; Generations; Goals; Grant; Head and Neck Cancer; Head and Neck Neoplasms; Head and neck structure; Industry; Knowledge; Laboratory Finding; Lead; Malignant Neoplasms; Medical; Michigan; Minority; Oncologist; Oral; Otolaryngologist; Outcome; Participant; Pathologist; Patient Care; Patients; Play; Process; Public Health; Publishing; Quality of life; Research; Research Methodology; Research Personnel; Research Project Grants; Role; Science; Scientist; Speed; Stem Cell Research; Stem cells; Surgeon; Therapeutic; Time; Translations; Travel; Universities; Woman; Work; abstracting; base; cancer stem cell; cancer type; carcinogenesis; clinical application; clinical practice; design; expectation; experience; head and neck cancer patient; improved; interest; malignant breast neoplasm; maxillofacial; meetings; melanoma; next generation; oncology; stem cell biology; stem cell population; symposium; tumor; tumor growth; tumor progression; tumorigenic

DESCRIPTION (provided by applicant): The First Symposium on Head and Neck Cancer Stem Cells is planned for May 10-11, 2012, at the campus of the University of Michigan in Ann Arbor. Stem cells play an important role in the pathobiology of cancer. However, the impact of stem cells in the initiation and progression of cancer is tumor-type specific. While in certain tumors most cells are highly tumorigenic (e.g. melanoma), in others there is a small sub-population of stem cells that are the primary responsible for the initiation and progression of the tumor (e.g. breast cancer). This Symposium will be the first one to focus on the role of stem cells in head and neck carcinogenesis. The understanding of the biology of stem cells in head and neck cancer is pivotal for the development of new strategies to identify these cells and to selectively eliminate their contribution to tumor growth and progression. The overall goal of this Symposium is to present and discuss the most recent advances in the area of cancer stem cell biology, stimulate state-of-the-art collaborative new research projects in this field, and use the new knowledge in the design of more efficacious and safer therapies for head and neck cancer patients. The specific aims of this Symposium are A) To present and discuss the state-of-the-science in cancer stem cell biology; B) To present and discuss the role of stem cells in the pathobiology of head and neck cancer; C) To identify challenges that impedes progress in head and neck cancer stem cell research and propose strategies to overcome these roadblocks; D) To foster lively scientific exchanges among leading scientists and young researchers engaged in cancer stem cell research; and E) To disseminate the symposium presentations by publishing its proceedings. We have worked extensively to attract outstanding scientists across a spectrum of disciplines for this Symposium. We expect that the audience will likely include dental and medical scientists, pathologists, oncologists, otolaryngologists, oral maxillofacial surgeons, biologists, and mathematicians with a common interest in stem cells and head and neck cancer. We anticipate 80-120 participants. The Symposium is organized in 4 main sessions over a period of 2 days, with 1 keynote talk, followed by 3 research talks, and ample time for discussion in each session. To cultivate the next generation of scientists, young investigators will be encouraged to attend by granting 12 travel awards distributed in a competitive basis, as well as by selecting up to 8 Abstracts from young investigators for short oral presentations. The organizing committee will provide careful consideration in selecting speakers and participants to foster a balanced audience and to ensure ample opportunities for participation of women, minorities, and persons with disabilities. The expected outcomes of this Symposium include the dissemination of the knowledge in this emerging area of head and neck oncology, the establishment of new research collaborations, and the acceleration of the translation of laboratory findings into improved therapies for patients suffering from head and neck cancer. PUBLIC HEALTH RELEVANCE: The relevance to public health of the proposed First Symposium on Head and Neck Cancer Stem Cells lies in its potential to accelerate the process of discovery of safer and more efficacious therapies for patients with advanced head and neck cancer. This is critical since the current benefits of therapy are modest for these patients, and their 5-year survival remains very low. The overall goal of this Symposium is to disseminate the most recent advances in the area of cancer stem cell biology and stimulate collaborative new research projects in this field, with the ultimate goal of developing new therapies that aim at improving the survival and quality of life of patients suffering from head and neck cancer.

描述（由申请人提供）：计划于2012年5月10日至11日在密歇根大学安阿伯大学的校园举行的头颈癌干细胞上的第一次研讨会。干细胞在癌症病理学中起重要作用。然而，干细胞在癌症开始和进展中的影响是肿瘤类型的特异性。在某些肿瘤中，大多数细胞是高度肿瘤性的（例如黑色素瘤），而在其他肿瘤中，干细胞的少量亚群是主要负责肿瘤起步和进展（例如乳腺癌）。该研讨会将是第一个专注于干细胞在头颈癌变中的作用的研讨会。对头颈癌中干细胞生物学的理解对于开发新策略以识别这些细胞并有选择地消除其对肿瘤生长和进展的贡献至关重要。该研讨会的总体目标是介绍和讨论癌症干细胞生物学领域的最新进展，刺激该领域的最新合作新研究项目，并在设计对头和颈癌患者的更有效，更安全的疗法时使用新知识。该研讨会的具体目的是a）介绍和讨论癌症干细胞生物学的最先进； b）介绍和讨论干细胞在头颈癌病理生物学中的作用； c）确定阻碍头颈癌干细胞研究进展的挑战，并提出克服这些障碍的策略； d）在从事癌症干细胞研究的主要科学家和年轻研究人员中培养生动的科学交流； e）通过发布诉讼程序来传播研讨会的演讲。我们已经广泛努力吸引跨该研讨会的各种学科的杰出科学家。我们预计观众可能会包括牙科和医学科学家，病理学家，肿瘤学家，耳鼻喉科医生，口腔上颌面外科医生，生物学家和数学家，对干细胞和头颈癌具有共同的兴趣。我们预计将有80-120参与者。研讨会在2天的时间内在4个主要会议中组织，并进行了1个主题演讲，然后进行了3场研究演讲，并在每节课中进行了充足的讨论时间。为了培养下一代科学家，将鼓励年轻的调查人员参加竞争性的12个旅行奖，以及通过从年轻调查员那里选择8位摘要以进行简短的口头演讲，以授予12个旅行奖。组织委员会将在选择演讲者和参与者时仔细考虑以培养平衡的受众，并确保妇女，少数民族和残疾人参与的机会。该研讨会的预期结果包括在此新兴领域的头颈肿瘤学领域，建立新的研究合作的建立以及将实验室发现转化为患有头颈癌患者改进的治疗疗法的知识的传播。 公共卫生相关性：与颈部和颈部癌干细胞的首次首次研讨会的公共卫生相关性在于它的潜力，可以加快发现晚期和颈癌患者的发现更安全，更有效率的疗法的过程。这至关重要，因为目前的治疗对这些患者的益处适中，并且他们的5年生存率仍然很低。该研讨会的总体目标是传播癌症干细胞生物学领域的最新进展，并刺激该领域的合作新研究项目，其最终目标是开发新疗法，旨在改善患有头颈癌患者的生存和生活质量。