Body Composition, Thermoregulation and food Intake Behavior Core

身体成分、体温调节和食物摄入行为核心

• 批准号: 8204177
• 负责人: Sean Harrison Adams
• 金额: $ 12.51万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8204177
• 关键词: Adipose tissue; Animals; Behavior; Biological Assay; Biology; Body Composition; Body Weight; Client; Complement; Complications of Diabetes Mellitus; Diabetic mouse; Disease; Eating; Feasibility Studies; Food; Goals; Human; Institutes; Metabolic; Metabolism; Mission; Molecular; Mus; Neurons; Obesity; Pathogenesis; Peripheral; Phenotype; Physiologic Thermoregulation; Physiology; Pilot Projects; Population; Procedures; Regulation; Research Personnel; Role; Services; Signal Transduction; System; Testing; Thermogenesis; design; energy balance; human disease; mouse model; research and development

The primary mission ofthe MMPC-UCD Body Composition, Thermoregulation, and Food Intake Behavior Core is to provide our clients with in-depth assessements of molecular and whole-animal phenomena relevant to body weight regulation and metabolism. In addition to providing essential basic metabolic phenotyping services and expertise, the Core has a unique strength in the application of challenge tests designed to unmask subtle phenotypes associated with energy balance and gut function. In addition, the Core will conduct pilot and feasibility studies with a goal to institute new mouse phenotyping approaches that will be useful to the MMPC-UCD and the MMPC system as a whole. Investigators participating in this Core have proven capabilities in studying mouse thermogenesis, adipose tissue biology, and energy balance regulators including gut signals. The MMPC-UCD Body Composition, Thermoregulation, and Food Intake Behavior Core will employ assays that complement and extend those offered by existing MMPCs, using state-of-the-art approaches and a unique perspective that includes an appreciation ofthe roles of gut physiology and peripheral neuron function.

MMPC-UCD身体组成，温度调节和食物摄入行为核心的主要任务是为我们的客户提供与体重调节和代谢有关的分子和全动物现象的深入评估。除了提供基本的基本代谢表型服务和专业知识外，该核心在应用挑战测试方面具有独特的优势，旨在揭示与能量平衡和肠道功能相关的微妙表型。此外，核心将以一个目标进行试验和可行性研究，以制定新的小鼠表型方法，这些方法将对MMPC-UCD和整个MMPC系统有用。参与此核心的研究人员在研究小鼠的热生成，脂肪组织生物学和包括肠道信号（包括肠道信号）的能量平衡调节剂方面具有证实的能力。 MMPC-UCD身体组成，温度调节和食物摄入行为核心将采用补充和扩展现有MMPC提供的测定方法，采用最新方法以及独特的观点，其中包括对肠道生理学和外周神经元功能的欣赏。