Body Composition, Thermoregulation and food Intake Behavior Core

MMPC-UCD身体组成、体温调节和食物摄入行为核心的主要任务是为客户提供与体重调节和代谢相关的分子和全动物现象的深入评估。除了提供必要的基本代谢表型服务和专业知识外，Core在应用挑战测试方面具有独特的优势，旨在揭示与能量平衡和肠道功能相关的微妙表型。此外，该中心将进行试点和可行性研究，目标是建立新的小鼠表型方法，这将对MMPC- ucd和整个MMPC系统有用。参与该核心的研究人员在研究小鼠产热、脂肪组织生物学和包括肠道信号在内的能量平衡调节方面已经证明了自己的能力。MMPC-UCD身体成分、体温调节和食物摄入行为核心将采用最先进的方法和独特的视角，包括对肠道生理学和周围神经元功能的作用的欣赏，补充和扩展现有mmpc提供的检测。

The primary mission ofthe MMPC-UCD Body Composition, Thermoregulation, and Food Intake Behavior Core is to provide our clients with in-depth assessements of molecular and whole-animal phenomena relevant to body weight regulation and metabolism. In addition to providing essential basic metabolic phenotyping services and expertise, the Core has a unique strength in the application of challenge tests designed to unmask subtle phenotypes associated with energy balance and gut function. In addition, the Core will conduct pilot and feasibility studies with a goal to institute new mouse phenotyping approaches that will be useful to the MMPC-UCD and the MMPC system as a whole. Investigators participating in this Core have proven capabilities in studying mouse thermogenesis, adipose tissue biology, and energy balance regulators including gut signals. The MMPC-UCD Body Composition, Thermoregulation, and Food Intake Behavior Core will employ assays that complement and extend those offered by existing MMPCs, using state-of-the-art approaches and a unique perspective that includes an appreciation ofthe roles of gut physiology and peripheral neuron function.