Body Composition, Thermoregulation and food Intake Behavior Core

身体成分、体温调节和食物摄入行为核心

• 批准号: 8204177
• 负责人: Sean Harrison Adams
• 金额: $ 12.51万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8204177
• 关键词: Adipose tissue; Animals; Behavior; Biological Assay; Biology; Body Composition; Body Weight; Client; Complement; Complications of Diabetes Mellitus; Diabetic mouse; Disease; Eating; Feasibility Studies; Food; Goals; Human; Institutes; Metabolic; Metabolism; Mission; Molecular; Mus; Neurons; Obesity; Pathogenesis; Peripheral; Phenotype; Physiologic Thermoregulation; Physiology; Pilot Projects; Population; Procedures; Regulation; Research Personnel; Role; Services; Signal Transduction; System; Testing; Thermogenesis; design; energy balance; human disease; mouse model; research and development

The primary mission ofthe MMPC-UCD Body Composition, Thermoregulation, and Food Intake Behavior Core is to provide our clients with in-depth assessements of molecular and whole-animal phenomena relevant to body weight regulation and metabolism. In addition to providing essential basic metabolic phenotyping services and expertise, the Core has a unique strength in the application of challenge tests designed to unmask subtle phenotypes associated with energy balance and gut function. In addition, the Core will conduct pilot and feasibility studies with a goal to institute new mouse phenotyping approaches that will be useful to the MMPC-UCD and the MMPC system as a whole. Investigators participating in this Core have proven capabilities in studying mouse thermogenesis, adipose tissue biology, and energy balance regulators including gut signals. The MMPC-UCD Body Composition, Thermoregulation, and Food Intake Behavior Core will employ assays that complement and extend those offered by existing MMPCs, using state-of-the-art approaches and a unique perspective that includes an appreciation ofthe roles of gut physiology and peripheral neuron function.

MMPC-UCD身体成分，体温调节和食物摄入行为核心的主要使命是为我们的客户提供与体重调节和代谢相关的分子和整体动物现象的深入评估。除了提供必要的基本代谢表型分析服务和专业知识外，Core还在挑战测试的应用方面具有独特的优势，旨在揭示与能量平衡和肠道功能相关的微妙表型。此外，核心将进行试点和可行性研究，目标是建立新的小鼠表型方法，这将有助于MMPC-UCD和MMPC系统作为一个整体。参与该核心的研究人员在研究小鼠产热、脂肪组织生物学和能量平衡调节剂（包括肠道信号）方面具有公认的能力。MMPC-UCD身体成分，体温调节和食物摄入行为核心将采用补充和扩展现有MMPC提供的检测方法，使用最先进的方法和独特的视角，包括肠道生理学和外周神经元功能的作用。