California Partnership for Personalized Nutrition
加州个性化营养合作伙伴关系
基本信息
- 批准号:10669429
- 负责人:
- 金额:$ 100万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-10 至 2023-08-09
- 项目状态:已结题
- 来源:
- 关键词:AddressAdvisory CommitteesAll of Us Research ProgramArtificial IntelligenceBehaviorBig DataBig Data MethodsBiological MarkersBloodCaliforniaCarbohydratesCessation of lifeCharacteristicsChemistryChronobiologyClinical NutritionCollaborationsCollectionCommunicationCommunitiesComplexConsentCoupledCrossover DesignDataData CollectionDietDiet HabitsDietary InterventionDietary PracticesDomicilesEatingEating BehaviorEcologyElectronic Health RecordEmerging TechnologiesEnrollmentEnvironmentEnvironmental Risk FactorEpigenetic ProcessExposure toFatty acid glycerol estersFoodGeneticGoalsHealthHealth FoodHealth PersonnelHormonesHumanHungerIndividualInterventionKineticsLipidsMarketingMeasurementMeasuresMedical centerMetabolicMetabolismMetagenomicsMethodsMicrobeMicronutrientsModernizationNational Health ProgramsNatureNon-Insulin-Dependent Diabetes MellitusNutrientNutritionalNutritional ScienceNutritionistOutcomeParticipantPatternPersonsPhasePhenotypePhysical activityPhysiologicalPhysiologyPopulationPopulation HeterogeneityPrecision HealthPrediabetes syndromeProtocols documentationPublic HealthRecommendationResearch DesignRiskRural CommunitySatiationStandardizationSubgroupSystemTechnologyTestingTimeTrainingType 2 diabeticUnhealthy DietUnited States National Institutes of HealthUrban CommunityUrinebiological systemsblood glucose regulationclinical centercohortcommunity based participatory researchcommunity-level factordata modelingdata sharingdesigndiabeticdietarydigitalexpectationexperiencefeedinggenomic datagut microbiotaimprovedindexingindividual responseindividual variationinnovationinter-individual variationmembermetabolomicsmetatranscriptomicsmicrobiomemicrobiotamultiple omicsnon-diabeticnutritionorganizational structureprecision medicineprecision nutritionprematureprogramsprototypepsychosocialrecruitresponsesedentary lifestylesocial factorssuburban communitiessynergismwearable device
项目摘要
Project Summary: Poor diet and sedentary behaviors are associated with some of the leading causes of
premature death in the U.S. While nutritionists understand that there are a variety of eating behaviors that have
positive benefits to health and function in general terms, it has been difficult to tailor dietary recommendations to
the individual. Public health recommendations and marketing that aim to improve ‘diet quality’ (or complementary
outcomes, such as physical activity) have been hampered by a broad brush ‘one-size fits all’ approach without
distinguishing individualized needs. A big challenge to design of strategies for more personalized public health
is the paucity of large-scale interventions that have tested person-to-person differences in physiological
responses to standardized foods or diet patterns. The premise of the NIH Nutrition for Precision Health program
and this application to establish the California Partnership for Personalized Nutrition Clinical Center is that
variance in dietary patterns and physiological responses to patterns and specific foods are shaped by disparate
factors including complex genetic, microbiome, psychosocial, human ecology, and metabolic variables. We aim
to examine which factor or combination of factors influence responses to a test meal composed of strategic
ingredients that interrogate multiple biological systems in parallel, population-wide but with a consideration of
sub-groups that differ with respect to glucose control and microbiome (type 2 diabetic, pre-diabetic, and non-
diabetic persons). In addition, the differential (intra- and interindividual) responses to three disparate diets
(Mediterranean, low-carbohydrate, and high-carbohydrate) will be tested in free-living and domiciled conditions,
to characterize microbiota shifts and to associate diet with changes in multi-system physiology and
chronobiology. Finally, the study design also provides biospecimens for metabolomics, chemistry, and
microbiome; advanced metabolic physiology data; innovative app and wearable derived data; in addition to core
protocol EMR and genomic data suitable for high quality data modeling and advanced statistical/artificial
intelligence “big data” methods for discovery of personalized nutritional optimization.
The California Partnership for Personalized Nutrition established in this project grows out of the California
Precision Medicine Consortium (CAPMC), the All of Us Health Provider Organization in California,. The CAPMC
has established teamwork Statewide for recruitment and retention, with engagement of the great diversity of the
population of the State of California. This team, combined with the considerable experience in clinical nutrition,
feeding studies and micro- and macro-nutrient assessment, digital app and wearable technologies, modern
human ecology, community alliances, and food for health and wellness provides a combination ideally suited to
the goals of the Nutrition for Precision Health National program.
项目总结:不良的饮食习惯和久坐不动的行为与一些主要原因有关
项目成果
期刊论文数量(0)
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Sean Harrison Adams其他文献
Sean Harrison Adams的其他文献
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{{ truncateString('Sean Harrison Adams', 18)}}的其他基金
California Partnership for Personalized Nutrition
加州个性化营养合作伙伴关系
- 批准号:
10386527 - 财政年份:2021
- 资助金额:
$ 100万 - 项目类别:
California Partnership for Personalized Nutrition
加州个性化营养合作伙伴关系
- 批准号:
10540243 - 财政年份:2021
- 资助金额:
$ 100万 - 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
- 批准号:
7809146 - 财政年份:2009
- 资助金额:
$ 100万 - 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
- 批准号:
8308909 - 财政年份:2008
- 资助金额:
$ 100万 - 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
- 批准号:
7688580 - 财政年份:2008
- 资助金额:
$ 100万 - 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
- 批准号:
8118833 - 财政年份:2008
- 资助金额:
$ 100万 - 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
- 批准号:
7903969 - 财政年份:2008
- 资助金额:
$ 100万 - 项目类别:
Body Composition, Thermoregulation and food Intake Behavior Core
身体成分、体温调节和食物摄入行为核心
- 批准号:
8204177 - 财政年份:
- 资助金额:
$ 100万 - 项目类别:
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Standard Grant