California Partnership for Personalized Nutrition

加州个性化营养合作伙伴关系

基本信息

  • 批准号:
    10669429
  • 负责人:
  • 金额:
    $ 100万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-10 至 2023-08-09
  • 项目状态:
    已结题

项目摘要

Project Summary: Poor diet and sedentary behaviors are associated with some of the leading causes of premature death in the U.S. While nutritionists understand that there are a variety of eating behaviors that have positive benefits to health and function in general terms, it has been difficult to tailor dietary recommendations to the individual. Public health recommendations and marketing that aim to improve ‘diet quality’ (or complementary outcomes, such as physical activity) have been hampered by a broad brush ‘one-size fits all’ approach without distinguishing individualized needs. A big challenge to design of strategies for more personalized public health is the paucity of large-scale interventions that have tested person-to-person differences in physiological responses to standardized foods or diet patterns. The premise of the NIH Nutrition for Precision Health program and this application to establish the California Partnership for Personalized Nutrition Clinical Center is that variance in dietary patterns and physiological responses to patterns and specific foods are shaped by disparate factors including complex genetic, microbiome, psychosocial, human ecology, and metabolic variables. We aim to examine which factor or combination of factors influence responses to a test meal composed of strategic ingredients that interrogate multiple biological systems in parallel, population-wide but with a consideration of sub-groups that differ with respect to glucose control and microbiome (type 2 diabetic, pre-diabetic, and non- diabetic persons). In addition, the differential (intra- and interindividual) responses to three disparate diets (Mediterranean, low-carbohydrate, and high-carbohydrate) will be tested in free-living and domiciled conditions, to characterize microbiota shifts and to associate diet with changes in multi-system physiology and chronobiology. Finally, the study design also provides biospecimens for metabolomics, chemistry, and microbiome; advanced metabolic physiology data; innovative app and wearable derived data; in addition to core protocol EMR and genomic data suitable for high quality data modeling and advanced statistical/artificial intelligence “big data” methods for discovery of personalized nutritional optimization. The California Partnership for Personalized Nutrition established in this project grows out of the California Precision Medicine Consortium (CAPMC), the All of Us Health Provider Organization in California,. The CAPMC has established teamwork Statewide for recruitment and retention, with engagement of the great diversity of the population of the State of California. This team, combined with the considerable experience in clinical nutrition, feeding studies and micro- and macro-nutrient assessment, digital app and wearable technologies, modern human ecology, community alliances, and food for health and wellness provides a combination ideally suited to the goals of the Nutrition for Precision Health National program.
项目总结:不良的饮食习惯和久坐不动的行为与一些主要原因有关

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Sean Harrison Adams其他文献

Sean Harrison Adams的其他文献

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{{ truncateString('Sean Harrison Adams', 18)}}的其他基金

Metabolism and Metabolic Health Core
新陈代谢和代谢健康核心
  • 批准号:
    10588974
  • 财政年份:
    2023
  • 资助金额:
    $ 100万
  • 项目类别:
California Partnership for Personalized Nutrition
加州个性化营养合作伙伴关系
  • 批准号:
    10386527
  • 财政年份:
    2021
  • 资助金额:
    $ 100万
  • 项目类别:
California Partnership for Personalized Nutrition
加州个性化营养合作伙伴关系
  • 批准号:
    10540243
  • 财政年份:
    2021
  • 资助金额:
    $ 100万
  • 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
  • 批准号:
    7809146
  • 财政年份:
    2009
  • 资助金额:
    $ 100万
  • 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
  • 批准号:
    8308909
  • 财政年份:
    2008
  • 资助金额:
    $ 100万
  • 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
  • 批准号:
    7688580
  • 财政年份:
    2008
  • 资助金额:
    $ 100万
  • 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
  • 批准号:
    8118833
  • 财政年份:
    2008
  • 资助金额:
    $ 100万
  • 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
  • 批准号:
    7903969
  • 财政年份:
    2008
  • 资助金额:
    $ 100万
  • 项目类别:
Body Composition, Thermoregulation and food Intake Behavior Core
身体成分、体温调节和食物摄入行为核心
  • 批准号:
    8204177
  • 财政年份:
  • 资助金额:
    $ 100万
  • 项目类别:

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