Mentoring in Arrhythmia Research

心律失常研究的指导

• 批准号: 8029253
• 负责人: Patrick Thomas Ellinor
• 金额: $ 12.73万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-03 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8029253
• 关键词: Affect; American; Arrhythmia; Atrial Fibrillation; Cardiac; Cessation of life; Clinical; Clinical Investigator; Clinical Research; Complement; Dementia; Development; Elderly; Exposure to; Family; Funding; General Hospitals; Genes; Genetic; Goals; Heart failure; Hypertension; International; Laboratories; Lead; Learning; Massachusetts; Mentors; Obesity; Pathogenesis; Pathway interactions; Patients; Public Health; Recording of previous events; Research; Research Activity; Research Methodology; Research Personnel; Resources; Risk; Risk Factors; Stroke; Training; Universities; Work; bench to bedside; cohort; cost; heart rhythm; interest; male; mortality; novel; patient oriented; patient oriented research; programs; sex; socioeconomics; success

DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common arrhythmia and affects over 2 million Americans, a number that is expected to rise to between 6 and 12 million by 2050. AF is a major public health burden as it is associated with a five-fold increased stroke risk, doubling in dementia risk, tripling in heart failure risk, and nearly two-fold increase in mortality. Many risk factors for AF have been identified, including advancing age, male sex, hypertension, heart failure, obesity and family history. Despite the profound socioeconomic costs of AF, our understanding of the fundamental mechanisms for the arrhythmia remains limited. The central goal of the candidate's research is to identify novel genes and pathways for AF. The candidate is a cardiac electrophysiologist with a bench to bedside research focus on AF. He has developed a cohort of patients with lone AF, leads an international consortium of investigators studying the genetics of AF, and performs laboratory work on the mechanisms of AF. Despite the success that the candidate has had in developing an arrhythmia research program, his current clinical commitments are limiting his exposure to the increasing number of fellows that he is mentoring. Therefore, the specific aims of this application are to provide the candidate long-term support to enable a reduction in his clinical commitments, and thus expand the training of mentees interested in pursuing patient-oriented arrhythmia research. Research mentees will have a rich diversity of opportunities to participate in patient-oriented research through the MGH AF study, the CHARGE-AF Consortium, and the candidate's own translational laboratory work. The fellow's research activities will be complemented by the extensive educational resources available at Massachusetts General Hospital and Harvard University. Ultimately, if funded, this application will contribute to the development of new clinical investigators in arrhythmia research and will catalyze understanding of this common and morbid arrhythmia. PUBLIC HEALTH RELEVANCE: Lay Narrative: Atrial fibrillation, a common, irregular heart rhythm, increases the risk of stroke and death. Despite affecting over 2 million Americans, relatively little is known about the underlying mechanisms that lead to atrial fibrillation. The goal of this application is to support Dr. Patrick T. Ellinor's efforts to train new investigators in clinical research methods in order to learn more about the pathogenesis of this common arrhythmia.

描述（由申请人提供）：房颤（AF）是最常见的心律失常，影响超过200万美国人，预计到2050年这一数字将上升到600万至1200万之间。房颤是一个主要的公共卫生负担，因为它与中风风险增加五倍、痴呆风险增加一倍、心力衰竭风险增加三倍、死亡率增加近两倍相关。房颤的许多危险因素已被确定，包括高龄、男性、高血压、心力衰竭、肥胖和家族史。尽管AF的社会经济成本很高，但我们对心律失常的基本机制的理解仍然有限。该候选人研究的中心目标是识别AF的新基因和途径。该候选人是一名心脏电生理学家，从实验室到床边的研究重点是AF。他已经开发了一个单发AF患者队列，领导一个国际研究人员联盟研究AF的遗传学，并对AF的机制进行实验室工作。尽管该候选人在制定心律失常研究计划方面取得了成功，他目前的临床工作限制了他与越来越多的他所指导的研究员的接触。因此，这项申请的具体目的是为候选人提供长期支持，以减少他的临床工作量，从而扩大对以患者为导向的心律失常研究感兴趣的学员的培训。研究学员将有丰富多样的机会通过MGH AF研究、CHARGE-AF联盟和候选人自己的转化实验室工作参与以患者为导向的研究。该研究员的研究活动将得到麻省总医院和哈佛大学广泛的教育资源的补充。最终，如果获得资助，该申请将有助于心律失常研究中新的临床研究者的发展，并将促进对这种常见和病态心律失常的理解。