Mentoring in Arrhythmia Research

心律失常研究的指导

• 批准号: 8204448
• 负责人: Patrick Thomas Ellinor
• 金额: $ 12.73万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-03 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8204448
• 关键词: 1q21; 4q25; Affect; Aging; American; Arrhythmia; Atrial Fibrillation; Candidate Disease Gene; Cardiac; Cardiovascular Diseases; Cessation of life; Chromosomes; Chromosomes, Human, Pair 16; Clinical; Clinical Investigator; Clinical Research; Cohort Studies; Complement; DNA Resequencing; Data; Dementia; Development; Elderly; Enhancers; Epidemiology; Exposure to; Faculty; Family; Framingham Heart Study; Functional RNA; Funding; Gap Junctions; General Hospitals; Genes; Genetic; Genome; Genomics; Goals; Heart; Heart failure; Heritability; Hypertension; Individual; International; Laboratories; Lead; Learning; Maps; Massachusetts; Mentors; Mutation; Obesity; Pathogenesis; Pathway interactions; Patients; Potassium Channel; Predisposition; Public Health; Recording of previous events; Reporting; Research; Research Activity; Research Methodology; Research Personnel; Research Training; Resources; Risk; Risk Factors; Screening procedure; Sodium Channel; Stroke; Training; Universities; Variant; Work; Zebrafish; abstracting; base; bench to bedside; cardiovascular disorder risk; cohort; cost; early onset; follow-up; gene function; genome wide association study; heart rhythm; interest; male; mortality; mouse model; novel; patient oriented; patient oriented research; programs; sex; socioeconomics; success; transcription factor

Abstract Atrial fibrillation (AF) is the most common arrhythmia and affects over 2 million Americans, a number that is expected to rise to between 6 and 12 million by 2050. AF is a major public health burden as it is associated with a five-fold increased stroke risk, doubling in dementia risk, tripling in heart failure risk, and nearly two-fold increase in mortality. Many risk factors for AF have been identified, including advancing age, male sex, hypertension, heart failure, obesity and family history. Despite the profound socioeconomic costs of AF, our understanding of the fundamental mechanisms for the arrhythmia remains limited. The central goal of the candidate's research is to identify novel genes and pathways for AF. The candidate is a cardiac electrophysiologist with a bench to bedside research focus on AF. He has developed a cohort of patients with lone AF, leads an international consortium of investigators studying the genetics of AF, and performs laboratory work on the mechanisms of AF. Despite the success that the candidate has had in developing an arrhythmia research program, his current clinical commitments are limiting his exposure to the increasing number of fellows that he is mentoring. Therefore, the specific aims of this application are to provide the candidate long-term support to enable a reduction in his clinical commitments, and thus expand the training of mentees interested in pursuing patient-oriented arrhythmia research. Research mentees will have a rich diversity of opportunities to participate in patient-oriented research through the MGH AF study, the CHARGE-AF Consortium, and the candidate's own translational laboratory work. The fellow's research activities will be complemented by the extensive educational resources available at Massachusetts General Hospital and Harvard University. Ultimately, if funded, this application will contribute to the development of new clinical investigators in arrhythmia research and will catalyze understanding of this common and morbid arrhythmia.

摘要 房颤是最常见的心律失常，影响着200多万美国人，这个数字是 预计到2050年将增至600万至1200万。房颤是一个主要的公共卫生负担，因为它与 中风风险增加五倍，痴呆症风险增加一倍，心力衰竭风险增加两倍， 死亡率的增加。房颤的危险因素很多，包括高龄、男性、 高血压、心力衰竭、肥胖和家族史。尽管房颤的社会经济代价高昂，但我们的 对心律失常的基本机制的了解仍然有限。该计划的中心目标 侯选人的研究是确定房颤的新基因和途径。 应聘者是一名心脏电生理学家，在床边专注于房颤的研究。他有 开发了一组孤立性房颤患者，领导了一个研究 房颤的遗传学，并对房颤的机制进行实验室工作。尽管取得了成功， 候选人已经开发了一项心律失常研究计划，他目前的临床承诺是有限的 他接触到了越来越多的他正在指导的研究员。因此，这一行动的具体目的是 申请是为候选人提供长期支持，以减少他的临床承诺， 从而扩大对有兴趣从事以患者为导向的心律失常研究的导师的培训。 研究指导对象将有丰富多样的机会通过以下方式参与以患者为中心的研究 MGH AF研究，Charge-AF联盟，以及候选人自己的翻译实验室工作。这个 Follow的研究活动将得到广泛的教育资源的补充，网址为 马萨诸塞州总医院和哈佛大学。最终，如果获得资金，这项应用程序将有助于 心律失常研究中新的临床研究人员的发展，并将促进对此的理解 常见的病理性心律失常。