Mentoring in Arrhythmia Research

心律失常研究的指导

• 批准号: 9321296
• 负责人: Patrick Thomas Ellinor
• 金额: $ 12.06万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-03 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9321296
• 关键词: 4q25; Affect; American; Area; Arrhythmia; Atrial Fibrillation; Award; Basic Science; Blood Circulation; Cardiac; Cardiopulmonary; Cardiovascular Diseases; Cessation of life; Chromosomes; Clinical; Clinical Investigator; Clinical Research; Complement; Dementia; Development; Elderly; Electrophysiology (science); Exposure to; Faculty; Family; Fellowship; Funding; General Hospitals; Genes; Genetic; Genetic study; Genomics; Goals; Heart failure; Heritability; Hospitalization; Hypertension; Individual; Institutes; International; Ion Channel; K-Series Research Career Programs; Laboratories; Lead; Learning; Manuscripts; Massachusetts; Mentors; Mid-Career Clinical Scientist Award (K24); Myocardial Infarction; Nature; Obesity; Pathogenesis; Pathway interactions; Patients; Positioning Attribute; Public Health; Public Health Schools; Publishing; Recording of previous events; Research; Research Methodology; Research Personnel; Research Training; Resources; Risk; Risk Factors; Series; Signal Transduction; Signaling Molecule; Stroke; Time; Training; Translations; Universities; Variant; Work; cardiovascular risk factor; cohort; cost; disorder risk; early onset; genetic variant; genome wide association study; heart rhythm; interest; male; member; mortality; novel; patient oriented; patient oriented research; programs; sex; socioeconomics; success; tool

Atrial fibrillation (AF) is the most common arrhythmia and affects over 3 million Americans, a number that is expected to rise to 12 million in 2050. AF is a major public health burden as it is associated with a five-fold increased stroke risk, doubling in dementia risk, tripling in heart failure risk, and nearly two-fold increase in mortality. Many risk factors for AF have been identified, including advancing age, male sex, hypertension, heart failure, obesity and family history. Despite the profound socioeconomic costs of AF, our understanding of the fundamental mechanisms for the arrhythmia remains largely unknown. The central goal of the candidate's research work is to use genetics to identify novel genes and pathways for AF. The candidate is a cardiac electrophysiologist with a research focus on atrial fibrillation. He has developed a cohort of patients with lone atrial fibrillation, leads an international consortium of investigators studying the genetics of atrial fibrillation, and performs laboratory work on the mechanisms of AF. Despite the initial success that candidate has had in developing a program in arrhythmia research, his clinical commitments had limited his exposure to the increasing number of fellows that he was mentoring. In 2010, the candidate received a K24 award entitled “Mentoring in Arrhythmia Research” that enable him to reduce his clinical time and focus on mentoring of his trainees. The time afforded by this award was transformative in the candidate's research program and his academic success. Therefore, the specific aims of this competitive renewal are to provide the candidate long-term support to enable a continued reduction in his clinical commitments, and to expand the research training of fellows interested patient-oriented research in atrial fibrillation and electrophysiology. Research fellows will have ample opportunities to participate in patient-oriented research through in the MGH AF study, the AFGen Consortium, and the candidates own translational laboratory work. These research opportunities will be complemented by the extensive educational resources available at Massachusetts General Hospital, the Broad Institute, and Harvard University. Ultimately, we hope that this proposal will contribute to the development of new clinical investigators in arrhythmia research and to further our understanding of this common and morbid arrhythmia.

心房颤动 (AF) 是最常见的心律失常，影响超过 300 万美国人，这一数字 预计到 2050 年将增加到 1200 万。房颤是一项重大的公共卫生负担，因为它与五倍的死亡率相关。 中风风险增加，痴呆风险增加一倍，心力衰竭风险增加三倍，心脏病风险增加近两倍 死亡。已经确定了许多 AF 的危险因素，包括年龄增长、男性、高血压、 心力衰竭、肥胖和家族史。尽管房颤造成了深远的社会经济成本，但我们对 心律失常的基本机制仍然很大程度上未知。候选人的中心目标 研究工作是利用遗传学来识别 AF 的新基因和途径。 该候选人是一位心脏电生理学家，主要研究心房颤动。他已经开发出 一群患有孤立性心房颤动的患者领导了一个国际研究人员联盟研究 房颤遗传学，并对 AF 机制进行实验室工作。尽管取得了初步成功 该候选人曾开发过心律失常研究项目，但他的临床承诺有限 他接触到了越来越多的他所指导的研究员。 2010 年，该候选人获得 K24 授予“心律失常研究指导”奖，使他能够减少临床时间并专注于 指导他的学员。该奖项提供的时间对候选人的研究具有变革性 计划和他的学术成功。 因此，本次竞争性续约的具体目的是为候选人提供长期支持 能够持续减少他的临床承诺，并扩大研究员的研究培训 对心房颤动和电生理学感兴趣的以患者为导向的研究。研究人员将有 通过 MGH AF 研究、AFGen 有充足的机会参与以患者为中心的研究 联盟和候选人拥有自己的翻译实验室工作。这些研究机会将 辅以马萨诸塞州总医院提供的广泛教育资源，布罗德 研究所和哈佛大学。最终，我们希望该提案能够为该领域的发展做出贡献。 新的临床研究人员进行心律失常研究，并进一步加深我们对这种常见病态的了解 心律失常。