Mentoring in Arrhythmia Research

心律失常研究的指导

• 批准号: 8387040
• 负责人: Patrick Thomas Ellinor
• 金额: $ 12.73万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-03 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8387040
• 关键词: 1q21; 4q25; Affect; Aging; American; Arrhythmia; Atrial Fibrillation; Candidate Disease Gene; Cardiac; Cardiovascular Diseases; Cessation of life; Chromosomes; Chromosomes, Human, Pair 16; Clinical; Clinical Investigator; Clinical Research; Cohort Studies; Complement; DNA Resequencing; Data; Dementia; Development; Elderly; Enhancers; Epidemiology; Exposure to; Faculty; Family; Framingham Heart Study; Functional RNA; Funding; Gap Junctions; General Hospitals; Genes; Genetic; Genome; Genomics; Goals; Heart; Heart failure; Heritability; Hypertension; Individual; International; Laboratories; Lead; Learning; Maps; Massachusetts; Mentors; Mutation; Obesity; Pathogenesis; Pathway interactions; Patients; Potassium Channel; Predisposition; Public Health; Recording of previous events; Reporting; Research; Research Activity; Research Methodology; Research Personnel; Research Training; Resources; Risk; Risk Factors; Sodium Channel; Stroke; Training; Universities; Variant; Work; Zebrafish; abstracting; base; bench to bedside; cardiovascular disorder risk; cohort; cost; early onset; follow-up; gene function; genome wide association study; heart rhythm; interest; male; mortality; mouse model; novel; patient oriented; patient oriented research; programs; screening; sex; socioeconomics; success; transcription factor

Abstract Atrial fibrillation (AF) is the most common arrhythmia and affects over 2 million Americans, a number that is expected to rise to between 6 and 12 million by 2050. AF is a major public health burden as it is associated with a five-fold increased stroke risk, doubling in dementia risk, tripling in heart failure risk, and nearly two-fold increase in mortality. Many risk factors for AF have been identified, including advancing age, male sex, hypertension, heart failure, obesity and family history. Despite the profound socioeconomic costs of AF, our understanding of the fundamental mechanisms for the arrhythmia remains limited. The central goal of the candidate's research is to identify novel genes and pathways for AF. The candidate is a cardiac electrophysiologist with a bench to bedside research focus on AF. He has developed a cohort of patients with lone AF, leads an international consortium of investigators studying the genetics of AF, and performs laboratory work on the mechanisms of AF. Despite the success that the candidate has had in developing an arrhythmia research program, his current clinical commitments are limiting his exposure to the increasing number of fellows that he is mentoring. Therefore, the specific aims of this application are to provide the candidate long-term support to enable a reduction in his clinical commitments, and thus expand the training of mentees interested in pursuing patient-oriented arrhythmia research. Research mentees will have a rich diversity of opportunities to participate in patient-oriented research through the MGH AF study, the CHARGE-AF Consortium, and the candidate's own translational laboratory work. The fellow's research activities will be complemented by the extensive educational resources available at Massachusetts General Hospital and Harvard University. Ultimately, if funded, this application will contribute to the development of new clinical investigators in arrhythmia research and will catalyze understanding of this common and morbid arrhythmia.

摘要 心房颤动（AF）是最常见的心律失常，影响超过200万美国人， 预计到2050年将增加到600万至1200万。AF是一个主要的公共卫生负担，因为它与 中风风险增加五倍，痴呆风险增加一倍，心力衰竭风险增加两倍， 死亡率上升。已经确定了房颤的许多风险因素，包括年龄增长，男性， 高血压、心力衰竭、肥胖和家族史。尽管AF的社会经济成本很高， 对心律失常的基本机制的理解仍然有限。的中心目标 候选人的研究是确定AF的新基因和途径。 该候选人是一名心脏电生理学家，他的临床研究重点是AF。 开发了一个孤立性房颤患者队列，领导了一个国际研究者联盟， 遗传学的AF，并进行实验室工作的AF的机制。尽管成功， 候选人在开发心律失常研究计划方面有困难，他目前的临床承诺有限 他接触到越来越多的他所指导的研究员。因此，这一具体目标 申请的目的是为候选人提供长期支持，以减少其临床承诺， 从而扩大对有兴趣进行以患者为导向的心律失常研究的学员的培训。 研究学员将有丰富多样的机会参与以患者为导向的研究， MGH AF研究，CHARGE-AF联盟，以及候选人自己的翻译实验室工作。的 研究员的研究活动将得到广泛的教育资源的补充， 马萨诸塞州总医院和哈佛大学。最终，如果获得资助，该应用程序将有助于 心律失常研究中新的临床研究者的发展，并将促进对这一点的理解 常见的病态心律失常