BONE BIOLOGY CORE

骨生物学核心

• 批准号: 8093265
• 负责人: MARK W HAMRICK
• 金额: $ 15.88万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8093265
• 关键词: Address; Affect; Age; Aging; Amino Acids; Animal Model; Area; Biochemical Markers; Biochemistry; Biological Assay; Biology; Biomechanics; Bone Marrow; Collection; Consultations; Data Collection; Densitometry; Environment; Fatty acid glycerol esters; Goals; Histology; Image; Impairment; Individual; Leptin; Link; Nutrient; Phenotype; Preparation; Program Research Project Grants; Research; Research Personnel; Serum; Services; Signal Transduction; Specimen; Stem cells; Stromal Cell-Derived Factor 1; Techniques; Technology; Time; bone; bone imaging; bone loss; bone metabolism; bone turnover; environmental change; experience; mouse model; new technology; programs; skeletal

The purpose of the Bone Biology Core (Core B) is to provide a standardized set of bone assay services that will facilitate completion ofthe broader goals and objections ofthe Program Project goals and specific aims. The objective of this Program Project application is to understand how age-associated changes in nutrient-related factors alters the environmental milieu of stem cells in bone. Each ofthe three projects investigates different aspects ofthese nutrient-related signals, yet all will employ similar techniques and animal models. The Bone Biology Core will provide each investigator with standard assay services in the areas of bone histology and histomorphometry, imaging, densitometry, biomechanics, and serum biochemistry. Dr. Mark Hamrick will be the core director. He is a bone biologist with experience and expertise in the areas of bone histomorphometry, densitometry, and biomechanics with particular emphasis on the use of animal models in bone metabolism research. He will be responsible for overseeing all administrative issues related to the Core B fadlities, as well as supervising the collection, preparation, and distribution of bone specimens. The Core will serve as the major center for data collection related to bone metabolism, and as such represents a key component linking the individual projects. Moreover, the Core seeks to develop new technologies in support of future research activities related to the objectives of the Program Project grant.

骨生物学核心（Core B）的目的是提供一套标准化的骨分析服务，以促进完成项目目标和具体目标的更广泛目标和异议。